| Gene Symbol | ANAPC11 |
|---|---|
| Entrez Gene | 51529 |
| Alt Symbol | APC11, Apc11p, HSPC214 |
| Species | Human |
| Gene Type | protein-coding |
| Description | anaphase promoting complex subunit 11 |
| Other Description | APC11 anaphase promoting complex subunit 11 homolog|anaphase promoting complex subunit 11 (yeast APC11 homolog)|anaphase-promoting complex subunit 11|cyclosome subunit 11|hepatocellular carcinoma-associated RING finger protein |
| Swissprots | A8MTT2 Q502X9 Q9BW64 Q9P0R2 B7ZW64 Q9NYG5 |
| Accessions | CAC24983 CAD61452 CAD61453 CAD61454 CAD61455 CAD61456 CAD61597 EAW89700 EAW89701 EAW89702 EAW89703 Q9NYG5 AA356010 AF151048 AAF36134 AF247565 AAF65816 AF247789 AAL95694 AI356704 AK091360 AK307214 AK308091 AW965775 BC000607 AAH00607 BC066308 AAH66308 BC095454 AAH95454 BC104641 AAI04642 BC171892 AAI71892 BC171898 AAI71898 BC171899 AAI71899 BC171900 AAI71900 BF435042 BF512771 BG707824 BM762129 BM845909 BU554167 BU556841 BY796995 CA335305 CB106395 DB501853 DB573049 HY067392 HY142453 NM_001002244 NP_001002244 NM_001002245 NP_001002245 NM_001002246 NP_001002246 NM_001002247 NP_001002247 NM_001002248 NP_001002248 NM_001002249 NP_001002249 NM_001289414 NP_001276343 NM_001289415 NP_001276344 NM_001289416 NP_001276345 NM_001289417 NP_001276346 NM_001289418 NP_001276347 NM_001289419 NP_001276348 NM_001289420 NP_001276349 NM_016476 NP_057560 |
| Function | Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11573242}. Nucleus {ECO:0000269|PubMed:11573242}. |
| Tissue Specificity | Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte. {ECO:0000269|PubMed:11573242}. |
| Top Pathways | Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection |
Human ANAPC11 cDNA clone(NM_016476.10) - CDFG000445 from Creative Biomart
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Human ANAPC11 cDNA clone(NM_001002244.1) - CDFH000757 from Creative Biomart
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Human ANAPC11 cDNA clone(NM_001002244.1) - CDFH000758 from Creative Biomart
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Human ANAPC11 cDNA clone(NM_001002245.1) - CDFH000759 from Creative Biomart
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Human ANAPC11 cDNA clone(NM_001002246.1) - CDFH000760 from Creative Biomart
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Human ANAPC11 cDNA clone(NM_001002248.1) - CDFH000761 from Creative Biomart
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Human ANAPC11 cDNA clone(NM_001002247.1) - CDFH000762 from Creative Biomart
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Human ANAPC11 cDNA clone(NM_001002249.1) - CDFH000763 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_016476.10) - CDCL153775 from Creative Biomart
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Human ANAPC11 ORF clone(NM_016476.10) - CDCH015619 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_016476.10) - CDCR301274 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_016476.10) - CDCR301275 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_016476.10) - CDCR301276 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002244.1) - CDCR338678 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002244.1) - CDCR338679 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002244.1) - CDCR338680 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002245.1) - CDCR338681 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002245.1) - CDCR338682 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002246.1) - CDCR338683 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002246.1) - CDCR338684 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002247.1) - CDCR338685 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002247.1) - CDCR338686 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002247.1) - CDCR338687 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002248.1) - CDCR338688 from Creative Biomart
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Human ANAPC11 ORF Clone(NM_001002248.1) - CDCR338689 from Creative Biomart
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