Gene Symbol | SMARCAL1 |
---|---|
Entrez Gene | 50485 |
Alt Symbol | HARP, HHARP |
Species | Human |
Gene Type | protein-coding |
Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 |
Other Description | ATP-driven annealing helicase|HepA-related protein|SMARCA-like protein 1|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1|sucrose nonfermenting protein 2-like 1 |
Swissprots | Q9UI93 Q9NXQ5 A6NEH0 Q53R00 Q96AY1 Q9NZC9 Q9UFH3 |
Accessions | AAF70454 AAX93097 EAW70567 Q9NZC9 AF082179 AAF24984 AF432223 AAL73034 AI701066 AK000117 BAA90955 AK023780 AL122076 CAB59251 BC016482 AAH16482 BC029994 BC043341 AAH43341 BX104166 DA856812 DB099423 DQ891737 ABM82663 DQ894913 ABM85839 XM_005246631 XP_005246688 XM_005246632 XP_005246689 XM_006712557 XP_006712620 NM_001127207 NP_001120679 NM_014140 NP_054859 |
Function | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19793862, ECO:0000269|PubMed:19793863}. Note=Recruited to damaged DNA regions. |
Tissue Specificity | Ubiquitously expressed, with high levels in testis. {ECO:0000269|PubMed:10857751, ECO:0000269|PubMed:11799392}. |
Human SmarcAL1 full length protein - ab162336 from Abcam
|
||||||||||
Human SmarcAL1 protein fragment - ab162337 from Abcam
|
||||||||||
SMARCAL1 Antibody Blocking Peptide - LS-E12148 from LifeSpan Bioscience
|
||||||||||
SMARCAL1 Antibody Blocking Peptide - LS-E12149 from LifeSpan Bioscience
|
||||||||||
SMARCAL1 Antibody Blocking Peptide - LS-E14080 from LifeSpan Bioscience
|
||||||||||
Recombinant Human SmarcAL1 Protein - H00050485-Q01 from Novus Biologicals
|
||||||||||
Recombinant Human SmarcAL1 Protein - H00050485-P01 from Novus Biologicals
|
||||||||||
SMARCAL1 / HARP - H00050485-P01 from Acris Antibodies
|
||||||||||
SMARCAL1 / HARP - H00050485-Q01-10 from Acris Antibodies
|
||||||||||
SMARCAL1 / HARP - H00050485-Q01-25 from Acris Antibodies
|
||||||||||
SMARCAL1 fusion protein - Ag23707 from Proteintech Group
|
||||||||||
SMARCAL1 fusion protein - Ag3194 from Proteintech Group
|
||||||||||
SMARCAL1 fusion protein - ag0867 from Proteintech Group
|
||||||||||
Recombinant Human SMARCAL1, GST-tagged - SMARCAL1-2806H from Creative Biomart
|
||||||||||
Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1(SMARCAL1) ,partial - CSB-YP885774HU CSB-EP885774HU CSB-BP885774HU CSB-MP885774HU from Cusabio
|
||||||||||
SmarcAL1 Protein - NBP2-13352PEP from Novus Biologicals
|
||||||||||
HARP-Antibody-Center-Blocking-Peptide - BP6864c from Abgent, a WuXi AppTec company
|
||||||||||
SMARCAL1 Peptide, Human - M34GP14727H from Creative Peptides
|
||||||||||
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (SMARCAL1), partial, Recombinant Protein - MBS1424297 from MyBioSource
|
||||||||||
Recombinant Human SMARCAL1 Protein, His-tagged - SMARCAL1-23H from Creative Biomart
|