| Gene Symbol | SMARCAL1 |
|---|---|
| Entrez Gene | 50485 |
| Alt Symbol | HARP, HHARP |
| Species | Human |
| Gene Type | protein-coding |
| Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 |
| Other Description | ATP-driven annealing helicase|HepA-related protein|SMARCA-like protein 1|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1|sucrose nonfermenting protein 2-like 1 |
| Swissprots | Q9UI93 Q9NXQ5 A6NEH0 Q53R00 Q96AY1 Q9NZC9 Q9UFH3 |
| Accessions | AAF70454 AAX93097 EAW70567 Q9NZC9 AF082179 AAF24984 AF432223 AAL73034 AI701066 AK000117 BAA90955 AK023780 AL122076 CAB59251 BC016482 AAH16482 BC029994 BC043341 AAH43341 BX104166 DA856812 DB099423 DQ891737 ABM82663 DQ894913 ABM85839 XM_005246631 XP_005246688 XM_005246632 XP_005246689 XM_006712557 XP_006712620 NM_001127207 NP_001120679 NM_014140 NP_054859 |
| Function | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:19793862, ECO:0000269|PubMed:19793863}. Note=Recruited to damaged DNA regions. |
| Tissue Specificity | Ubiquitously expressed, with high levels in testis. {ECO:0000269|PubMed:10857751, ECO:0000269|PubMed:11799392}. |
SmarcAL1 CRISPR/Cas9 KO Plasmid (h) - sc-405681 from Santa Cruz Biotechnology
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SmarcAL1 HDR Plasmid (h) - sc-405681-HDR from Santa Cruz Biotechnology
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SmarcAL1 Double Nickase Plasmid (h) - sc-405681-NIC from Santa Cruz Biotechnology
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SmarcAL1 Double Nickase Plasmid (h2) - sc-405681-NIC-2 from Santa Cruz Biotechnology
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SmarcAL1 CRISPR Activation Plasmid (h) - sc-405681-ACT from Santa Cruz Biotechnology
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SmarcAL1 CRISPR Activation Plasmid (h2) - sc-405681-ACT-2 from Santa Cruz Biotechnology
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SmarcAL1 Lentiviral Activation Particles (h) - sc-405681-LAC from Santa Cruz Biotechnology
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SmarcAL1 Lentiviral Activation Particles (h2) - sc-405681-LAC-2 from Santa Cruz Biotechnology
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SmarcAL1 siRNA (h) - sc-63042 from Santa Cruz Biotechnology
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SmarcAL1 shRNA Plasmid (h) - sc-63042-SH from Santa Cruz Biotechnology
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SmarcAL1 shRNA (h) Lentiviral Particles - sc-63042-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU068691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19765 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19765 from Sigma-Aldrich
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SMARCAL1 siRNA (Human) - CRH9371 from Cohesion Biosciences
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SMARCAL1 - MBS8230452 from MyBioSource
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shRNA set against Human SMARCAL1 (NM_014140.3) - SHH413136 from Creative biogene
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Human SMARCAL1 siRNA - orb269873 from Biorbyt
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SMARCAL1 shRNA Plasmid (Human) - CHH9371 from Cohesion Biosciences
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SMARCAL1 miRNA 3'UTR clone - MiUTR3H-08613 from Creative biogene
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SMARCAL1 miRNA 3'UTR clone - MiUTR3H-08614 from Creative biogene
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