| Gene Symbol |
TRABD2A
|
| Entrez Gene |
129293
|
| Alt Symbol |
C2orf89, TIKI1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TraB domain containing 2A
|
| Other Description |
TRAB domain-containing protein 2A|UPF0632 protein C2orf89|metalloprotease TIKI1
|
| Swissprots |
I6UMB9 Q86V40 B4DKK8
|
| Accessions |
EAW99549 EAW99551 EAW99552 Q86V40 AK128325 AK296608 BAG59220 AK309615 BC049209 BC051789 AAH51789 BC073808 BG170846 JQ653415 AFN02881 XM_005264131 XP_005264188 XM_011532504 XP_011530806 NM_001080824 NP_001074293 NM_001277053 NP_001263982 NM_001307978 NP_001294907
|
| Function |
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N- terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. {ECO:0000269|PubMed:22726442}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22726442}; Single-pass type I membrane protein {ECO:0000269|PubMed:22726442}.
|