| Gene Symbol | TRABD2A |
|---|---|
| Entrez Gene | 129293 |
| Alt Symbol | C2orf89, TIKI1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TraB domain containing 2A |
| Other Description | TRAB domain-containing protein 2A|UPF0632 protein C2orf89|metalloprotease TIKI1 |
| Swissprots | I6UMB9 Q86V40 B4DKK8 |
| Accessions | EAW99549 EAW99551 EAW99552 Q86V40 AK128325 AK296608 BAG59220 AK309615 BC049209 BC051789 AAH51789 BC073808 BG170846 JQ653415 AFN02881 XM_005264131 XP_005264188 XM_011532504 XP_011530806 NM_001080824 NP_001074293 NM_001277053 NP_001263982 NM_001307978 NP_001294907 |
| Function | Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N- terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. {ECO:0000269|PubMed:22726442}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:22726442}; Single-pass type I membrane protein {ECO:0000269|PubMed:22726442}. |
MISSION® esiRNA - EHU102101 from Sigma-Aldrich
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MISSION® esiRNA - EHU021721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4870 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4870 from Sigma-Aldrich
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TRABD2A siRNA (Human) - CRJ4996 from Cohesion Biosciences
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TRABD2A - MBS8221880 from MyBioSource
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shRNA set against Human C2ORF89 (NM_001080824.1) - SHH251525 from Creative biogene
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Human TRABD2A siRNA - orb275497 from Biorbyt
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TRABD2A shRNA Plasmid (Human) - CHJ4996 from Cohesion Biosciences
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TRABD2A miRNA 3'UTR clone - MiUTR3H-14127 from Creative biogene
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