Gene Symbol | RRM2 |
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Entrez Gene | 6241 |
Alt Symbol | R2, RR2, RR2M |
Species | Human |
Gene Type | protein-coding |
Description | ribonucleotide reductase M2 |
Other Description | ribonucleoside-diphosphate reductase subunit M2|ribonucleotide reductase M2 polypeptide|ribonucleotide reductase small chain|ribonucleotide reductase small subunit |
Swissprots | P31350 J3KP43 B2R9B5 Q5WRU7 |
Accessions | AAD53261 AAK51163 AAX93099 P31350 AK092671 BAG52588 AK123010 BAG53847 AK313719 BAG36462 BC001886 AAH01886 BC028932 AAH28932 BC030154 AAH30154 BM994533 DA477511 DQ891863 ABM82789 DQ895052 ABM85978 S40301 AAA09577 X59618 CAA42181 NM_001034 NP_001025 NM_001165931 NP_001159403 |
Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. |
Subcellular Location | Cytoplasm. |
Top Pathways | p53 signaling pathway, Purine metabolism, Glutathione metabolism, Pyrimidine metabolism |
R2 CRISPR/Cas9 KO Plasmid (h) - sc-400624 from Santa Cruz Biotechnology
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R2 HDR Plasmid (h) - sc-400624-HDR from Santa Cruz Biotechnology
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R2 Double Nickase Plasmid (h) - sc-400624-NIC from Santa Cruz Biotechnology
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R2 Double Nickase Plasmid (h2) - sc-400624-NIC-2 from Santa Cruz Biotechnology
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R2 CRISPR Activation Plasmid (h) - sc-400624-ACT from Santa Cruz Biotechnology
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R2 CRISPR Activation Plasmid (h2) - sc-400624-ACT-2 from Santa Cruz Biotechnology
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R2 Lentiviral Activation Particles (h) - sc-400624-LAC from Santa Cruz Biotechnology
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R2 Lentiviral Activation Particles (h2) - sc-400624-LAC-2 from Santa Cruz Biotechnology
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R2 siRNA (h) - sc-36338 from Santa Cruz Biotechnology
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R2 shRNA Plasmid (h) - sc-36338-SH from Santa Cruz Biotechnology
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R2 shRNA (h) Lentiviral Particles - sc-36338-V from Santa Cruz Biotechnology
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RRM2 RNAi - H00006241-R01 from Novus Biologicals
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MISSION® esiRNA - EHU121701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18686 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18686 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08332 from Sigma-Aldrich
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RRM2 siRNA (Human) - CRH4204 from Cohesion Biosciences
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RRM2 - MBS8237556 from MyBioSource
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R2 CRISPR/Cas9 KO Plasmid (h2) - sc-400624-KO-2 from Santa Cruz Biotechnology
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R2 HDR Plasmid (h2) - sc-400624-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human RRM2 (NM_001034.3) - SHH399964 from Creative biogene
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RRM2 shRNA Plasmid (Human) - CHH4204 from Cohesion Biosciences
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