| Gene Symbol |
TSPYL2
|
| Entrez Gene |
64061
|
| Alt Symbol |
CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TSPY-like 2
|
| Other Description |
CASK-interacting nucleosome assembly protein|CTCL tumor antigen se20-4|CTCL-associated antigen se20-4|TSPY-like protein 2|cell division autoantigen 1|cutaneous T-cell lymphoma-associated antigen se20-4|cutaneous T-cell lymphoma-associated tumor antigen se20-4|differentially expressed nucleolar TGF-beta1 target|differentially-expressed nucleolar TGF-beta1 target protein|nuclear protein of 79 kDa|testis-specific Y-encoded-like protein 2|testis-specific protein Y encoded-like 2
|
| Swissprots |
Q9H2G4 O94799 Q9BZW6 Q96DG7
|
| Accessions |
EAW93143 EAW93144 Q9H2G4 AB015345 BAA34802 AB209182 BAD92419 AF254794 AAG53596 AF273046 AAG34906 AI208075 AK131220 BAG54754 AK292462 BAF85151 AL713652 CAD28461 AM392716 CAL37594 AY040871 AAK72407 BC001566 AAH01566 BC024270 AAH24270 DA076199 XM_006724592 XP_006724655 NM_022117 NP_071400
|
| Function |
Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11318608, ECO:0000269|PubMed:11395479}. Cytoplasm {ECO:0000250}. Note=Enriched in transcriptionally active regions of chromatin in neurons. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas. {ECO:0000269|PubMed:11149944, ECO:0000269|PubMed:11318608, ECO:0000269|PubMed:12393179, ECO:0000269|PubMed:15241014}.
|