Gene Symbol | TSPYL2 |
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Entrez Gene | 64061 |
Alt Symbol | CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX |
Species | Human |
Gene Type | protein-coding |
Description | TSPY-like 2 |
Other Description | CASK-interacting nucleosome assembly protein|CTCL tumor antigen se20-4|CTCL-associated antigen se20-4|TSPY-like protein 2|cell division autoantigen 1|cutaneous T-cell lymphoma-associated antigen se20-4|cutaneous T-cell lymphoma-associated tumor antigen se20-4|differentially expressed nucleolar TGF-beta1 target|differentially-expressed nucleolar TGF-beta1 target protein|nuclear protein of 79 kDa|testis-specific Y-encoded-like protein 2|testis-specific protein Y encoded-like 2 |
Swissprots | Q9H2G4 O94799 Q9BZW6 Q96DG7 |
Accessions | EAW93143 EAW93144 Q9H2G4 AB015345 BAA34802 AB209182 BAD92419 AF254794 AAG53596 AF273046 AAG34906 AI208075 AK131220 BAG54754 AK292462 BAF85151 AL713652 CAD28461 AM392716 CAL37594 AY040871 AAK72407 BC001566 AAH01566 BC024270 AAH24270 DA076199 XM_006724592 XP_006724655 NM_022117 NP_071400 |
Function | Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11318608, ECO:0000269|PubMed:11395479}. Cytoplasm {ECO:0000250}. Note=Enriched in transcriptionally active regions of chromatin in neurons. {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas. {ECO:0000269|PubMed:11149944, ECO:0000269|PubMed:11318608, ECO:0000269|PubMed:12393179, ECO:0000269|PubMed:15241014}. |
CINAP CRISPR/Cas9 KO Plasmid (h) - sc-412969 from Santa Cruz Biotechnology
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CINAP HDR Plasmid (h) - sc-412969-HDR from Santa Cruz Biotechnology
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CINAP Double Nickase Plasmid (h) - sc-412969-NIC from Santa Cruz Biotechnology
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CINAP Double Nickase Plasmid (h2) - sc-412969-NIC-2 from Santa Cruz Biotechnology
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CINAP CRISPR Activation Plasmid (h) - sc-412969-ACT from Santa Cruz Biotechnology
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CINAP CRISPR Activation Plasmid (h2) - sc-412969-ACT-2 from Santa Cruz Biotechnology
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CINAP Lentiviral Activation Particles (h) - sc-412969-LAC from Santa Cruz Biotechnology
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CINAP Lentiviral Activation Particles (h2) - sc-412969-LAC-2 from Santa Cruz Biotechnology
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CINAP siRNA (h) - sc-72908 from Santa Cruz Biotechnology
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CINAP shRNA Plasmid (h) - sc-72908-SH from Santa Cruz Biotechnology
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CINAP shRNA (h) Lentiviral Particles - sc-72908-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU018321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22131 from Sigma-Aldrich
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TSPYL2 siRNA (Human) - CRJ1894 from Cohesion Biosciences
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CINAP RNAi - H00064061-R01 from Novus Biologicals
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TSPYL2 - MBS8217587 from MyBioSource
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shRNA set against Human TSPYL2 (NM_022117.3) - SHH436512 from Creative biogene
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Human TSPYL2 siRNA - orb272395 from Biorbyt
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TSPYL2 shRNA Plasmid (Human) - CHJ1894 from Cohesion Biosciences
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TSPYL2 miRNA 3'UTR clone - MiUTR3H-02849 from Creative biogene
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