Gene Symbol | TSPYL2 |
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Entrez Gene | 64061 |
Alt Symbol | CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX |
Species | Human |
Gene Type | protein-coding |
Description | TSPY-like 2 |
Other Description | CASK-interacting nucleosome assembly protein|CTCL tumor antigen se20-4|CTCL-associated antigen se20-4|TSPY-like protein 2|cell division autoantigen 1|cutaneous T-cell lymphoma-associated antigen se20-4|cutaneous T-cell lymphoma-associated tumor antigen se20-4|differentially expressed nucleolar TGF-beta1 target|differentially-expressed nucleolar TGF-beta1 target protein|nuclear protein of 79 kDa|testis-specific Y-encoded-like protein 2|testis-specific protein Y encoded-like 2 |
Swissprots | Q9H2G4 O94799 Q9BZW6 Q96DG7 |
Accessions | EAW93143 EAW93144 Q9H2G4 AB015345 BAA34802 AB209182 BAD92419 AF254794 AAG53596 AF273046 AAG34906 AI208075 AK131220 BAG54754 AK292462 BAF85151 AL713652 CAD28461 AM392716 CAL37594 AY040871 AAK72407 BC001566 AAH01566 BC024270 AAH24270 DA076199 XM_006724592 XP_006724655 NM_022117 NP_071400 |
Function | Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11318608, ECO:0000269|PubMed:11395479}. Cytoplasm {ECO:0000250}. Note=Enriched in transcriptionally active regions of chromatin in neurons. {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas. {ECO:0000269|PubMed:11149944, ECO:0000269|PubMed:11318608, ECO:0000269|PubMed:12393179, ECO:0000269|PubMed:15241014}. |
Human DENTT full length protein - ab163766 from Abcam
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TSPYL2 / DENTT Antibody Blocking Peptide - LS-E27814 from LifeSpan Bioscience
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TSPYL2 / DENTT Antibody Blocking Peptide - LS-E27815 from LifeSpan Bioscience
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TSPYL2 / DENTT Antibody Blocking Peptide - LS-E25266 from LifeSpan Bioscience
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TSPYL2 Immunizing peptide - orb66291 from Biorbyt
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DENTT Peptide - AC21-0094-P from Abcore
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DENTT Peptide - AC21-2625-P from Abcore
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DENTT Peptide - AC21-2626-P from Abcore
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TSPYL2 - H00064061-P01 from Acris Antibodies
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TSPYL2 Peptide - 42-955P from ProSci
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TSPYL2 Peptide - 42-458P from ProSci
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TSPYL2 Peptide - 42-954P from ProSci
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TSPYL2,TSPX,NP79 fusion protein - ag2722 from Proteintech Group
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Recombinant Human Testis-specific Y-encoded-like protein 2(TSPYL2) - CSB-YP887962HU CSB-EP887962HU CSB-BP887962HU CSB-MP887962HU from Cusabio
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Testis-specific Y-encoded-like protein 2 (TSPYL2), Recombinant Protein - MBS1431202 from MyBioSource
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DENTT/CDA1, Peptide - MBS428512 from MyBioSource
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TSPYL2, Peptide - MBS428383 from MyBioSource
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TSPYL2, Peptide - MBS427436 from MyBioSource
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CINAP Recombinant Protein Antigen - NBP1-91787PEP from Novus Biologicals
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TSPYL2-Blocking-Peptide-Center - BP20456c from Abgent, a WuXi AppTec company
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TSPYL2 Peptide, Human - M34GP16757H from Creative Peptides
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TSPYL2 Immunizing peptide - orb66292 from Biorbyt
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