| Gene Symbol |
PEBP1
|
| Entrez Gene |
5037
|
| Alt Symbol |
HCNP, HCNPpp, HEL-210, HEL-S-34, PBP, PEBP, PEBP-1, RKIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylethanolamine binding protein 1
|
| Other Description |
Raf kinase inhibitory protein|epididymis luminal protein 210|epididymis secretory protein Li 34|hippocampal cholinergic neurostimulating peptide|neuropolypeptide h3|phosphatidylethanolamine-binding protein 1|prostatic binding protein|prostatic-binding protein|raf kinase inhibitor protein
|
| Swissprots |
B2R4S1 P30086
|
| Accessions |
EAW98122 EAW98123 P30086 AK226006 AK299414 BAG61396 AK308056 AK311927 BAG34868 BC008714 AAH08714 BC017396 AAH17396 BC018799 BC031102 AAH31102 BF978793 D16111 BAA03684 EU668351 ACF94504 EU794643 ACJ13697 HM131449 ADI99998 S76773 AAD14234 X75252 CAA53031 X85033 CAA59404 NM_002567 NP_002558
|
| Function |
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
![Western Blot: PBP Overexpression Lysate (Adult Normal) [NBL1-14274] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PBP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7085_PBP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14274-img0002.jpg)