Gene Symbol | PEBP1 |
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Entrez Gene | 5037 |
Alt Symbol | HCNP, HCNPpp, HEL-210, HEL-S-34, PBP, PEBP, PEBP-1, RKIP |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidylethanolamine binding protein 1 |
Other Description | Raf kinase inhibitory protein|epididymis luminal protein 210|epididymis secretory protein Li 34|hippocampal cholinergic neurostimulating peptide|neuropolypeptide h3|phosphatidylethanolamine-binding protein 1|prostatic binding protein|prostatic-binding protein|raf kinase inhibitor protein |
Swissprots | B2R4S1 P30086 |
Accessions | EAW98122 EAW98123 P30086 AK226006 AK299414 BAG61396 AK308056 AK311927 BAG34868 BC008714 AAH08714 BC017396 AAH17396 BC018799 BC031102 AAH31102 BF978793 D16111 BAA03684 EU668351 ACF94504 EU794643 ACJ13697 HM131449 ADI99998 S76773 AAD14234 X75252 CAA53031 X85033 CAA59404 NM_002567 NP_002558 |
Function | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
SignalSilence ® RKIP siRNA I - 6296 from Cell Signaling Technology
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SignalSilence ® RKIP siRNA II - 6297 from Cell Signaling Technology
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RKIP CRISPR/Cas9 KO Plasmid (h) - sc-401270 from Santa Cruz Biotechnology
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RKIP HDR Plasmid (h) - sc-401270-HDR from Santa Cruz Biotechnology
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RKIP Double Nickase Plasmid (h) - sc-401270-NIC from Santa Cruz Biotechnology
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RKIP Double Nickase Plasmid (h2) - sc-401270-NIC-2 from Santa Cruz Biotechnology
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RKIP CRISPR Activation Plasmid (h) - sc-401270-ACT from Santa Cruz Biotechnology
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RKIP CRISPR Activation Plasmid (h2) - sc-401270-ACT-2 from Santa Cruz Biotechnology
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RKIP Lentiviral Activation Particles (h) - sc-401270-LAC from Santa Cruz Biotechnology
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RKIP Lentiviral Activation Particles (h2) - sc-401270-LAC-2 from Santa Cruz Biotechnology
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RKIP siRNA (h) - sc-36430 from Santa Cruz Biotechnology
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RKIP shRNA Plasmid (h) - sc-36430-SH from Santa Cruz Biotechnology
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RKIP shRNA (h) Lentiviral Particles - sc-36430-V from Santa Cruz Biotechnology
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RKIP/PBP RNAi - H00005037-R01 from Novus Biologicals
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MISSION® esiRNA - EHU012661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16605 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16605 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06336 from Sigma-Aldrich
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PEBP1 siRNA (Human) - CRH3349 from Cohesion Biosciences
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shRNA set against Human PEBP1 (NM_002567.2) - SHH373344 from Creative biogene
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shRNA set against Human PEBP1(NM_002567.2) - SHR103632 from Creative biogene
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PEBP1 shRNA Plasmid (Human) - CHH3349 from Cohesion Biosciences
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PEBP1 miRNA 3'UTR clone - MiUTR1H-07772 from Creative biogene
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