| Gene Symbol |
NEDD9
|
| Entrez Gene |
4739
|
| Alt Symbol |
CAS-L, CAS2, CASL, CASS2, HEF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neural precursor cell expressed, developmentally down-regulated 9
|
| Other Description |
Cas scaffolding protein family member 2|Crk-associated substrate related protein Cas-L|Enhancer of filamentation 1 p55|cas-like docking|enhancer of filamentation 1|neural precursor cell expressed developmentally down-regulated protein 9|p130Cas-related protein|renal carcinoma antigen NY-REN-12
|
| Swissprots |
Q5XKI0 A8MSJ9 A8K9G7 Q14511 G5E9Y9 Q5T9R4
|
| Accessions |
EAW55299 EAW55300 EAW55301 EAW55302 EAW55303 Q14511 AA814628 AJ420493 AK292682 BAF85371 AW963532 BC020686 AAH20686 BC040207 AAH40207 BC050740 BP262776 BX648041 DA660812 DA676780 DA778416 DQ891725 ABM82651 DQ894902 ABM85828 EU832525 ACE87697 EU832607 ACE87009 L43821 AAA98770 U64317 AAB53696 NM_001142393 NP_001135865 NM_001271033 NP_001257962 NM_006403 NP_006394 NM_182966 NP_892011 NR_073131
|
| Function |
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.
|
| Subcellular Location |
Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm. Cell junction, focal adhesion. Note=Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle.
|
| Tissue Specificity |
Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues.
|
