| Gene Symbol |
PHC1
|
| Entrez Gene |
1911
|
| Alt Symbol |
EDR1, HPH1, MCPH11, RAE28
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polyhomeotic homolog 1 (Drosophila)
|
| Other Description |
early development regulator 1 (homolog of polyhomeotic 1)|early development regulatory protein 1|polyhomeotic-like 1|polyhomeotic-like protein 1
|
| Swissprots |
Q9BU63 Q8WVM3 P78364 D3DUV4
|
| Accessions |
BAA83727 EAW88600 EAW88601 P78364 AB209063 BAD92300 AK293893 BAG57282 BC002871 AAH02871 BC017748 AAH17748 BC073964 AAH73964 BC157850 AAI57851 BM473731 BX640639 CAE45787 CN388283 CN388285 CN388316 U89277 AAC51169 XM_005253334 XP_005253391 XM_011520598 XP_011518900 XM_011520599 XP_011518901 XM_011520600 XP_011518902 XM_011520601 XP_011518903 XM_011520602 XP_011518904 XM_011520603 XP_011518905 NM_004426 NP_004417
|
| Function |
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. {ECO:0000269|PubMed:23418308}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21282530, ECO:0000269|PubMed:9121482}.
|