| Gene Symbol |
PTK7
|
| Entrez Gene |
5754
|
| Alt Symbol |
CCK-4, CCK4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine kinase 7 (inactive)
|
| Other Description |
PTK7 protein tyrosine kinase 7|colon carcinoma kinase 4|inactive tyrosine-protein kinase 7|pseudo tyrosine kinase receptor 7|tyrosine-protein kinase-like 7
|
| Swissprots |
Q8NFA5 Q13417 Q8NFA8 A8K974 Q6IQ54 Q5T650 Q8NFA7 B7Z477 E9PFZ5 Q8NFA6 Q13308
|
| Accessions |
AAL39062 EAX04154 EAX04155 EAX04156 EAX04157 EAX04158 EAX04159 EAX04160 Q13308 AB209350 BAD92587 AF531868 AAN04862 AF531869 AAN04863 AF531870 AAN04864 AF531871 AAN04865 AF531872 AAN04866 AI140260 AK055648 BAG51548 AK093428 AK097717 AK131487 AK291016 BAF83705 AK292589 BAF85278 AK296931 BAH12457 AK296953 BAH12463 AL157486 CAB75674 BC002377 BC014626 BC046109 AAH46109 BC071557 AAH71557 BM811107 BQ881986 CA389442 CN266652 DA048438 U33635 AAA87565 U40271 AAC50484 XM_011514765 XP_011513067 XM_011514766 XP_011513068 XR_926286 NM_001270398 NP_001257327 NM_002821 NP_002812 NM_152880 NP_690619 NM_152881 NP_690620 NM_152882 NP_690621 NR_072997 NR_072998 NM_152883
|
| Function |
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269|PubMed:18471990, ECO:0000269|PubMed:20558616, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21103379, ECO:0000269|PubMed:21132015}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:20837484}; Single-pass type I membrane protein {ECO:0000269|PubMed:20837484}. Cell junction {ECO:0000269|PubMed:20837484}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
|
| Tissue Specificity |
Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
|