LPAR2

Gene Symbol LPAR2
Entrez Gene 9170
Alt Symbol EDG-4, EDG4, LPA-2, LPA2
Species Human
Gene Type protein-coding
Description lysophosphatidic acid receptor 2
Other Description G protein-coupled receptor|LPA receptor 2|LPA receptor EDG4|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4|lysophosphatidic acid receptor EDG4|lysophosphatidic acid receptor Edg-4
Swissprots O00543 O43431 Q9HBW0
Accessions AAB61528 CCQ43276 CCV20022 EAW84836 EAW84837 Q9HBW0 AF011466 AAC27728 AF197929 AAG28521 AF233092 AAF43409 AK123043 BAG53861 AK316573 BAG38162 AU133824 AY322548 AAP84361 BC025695 AAH25695 BM840024 XM_011528417 XP_011526719 XM_011528418 XP_011526720 XM_011528419 XP_011526721 XM_011528420 XP_011526722 XM_011528421 XP_011526723 NM_004720 NP_004711
Function Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. {ECO:0000269|PubMed:15143197, ECO:0000269|PubMed:19306925}.
Subcellular Location Cell surface {ECO:0000269|PubMed:19306925}. Cell membrane {ECO:0000269|PubMed:19306925}; Multi-pass membrane protein {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
Tissue Specificity Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.
Top Pathways PI3K-Akt signaling pathway, Rap1 signaling pathway, Neuroactive ligand-receptor interaction

EDG-4 (H-55) - sc-25490 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EDG-4 (H-55): sc-25490. Western blot analysis of EDG-4 expression in BT-20 (A), MDA-MB-231 (B), ES-2 (C), OV-90 (D) and CHO-K1 (E) whole cell lysates.

EDG-4 (A-18) - sc-16081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

EDG-4 (C-16) - sc-16082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-EDG4 antibody - ab38322 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-EDG4 antibody (ab38322) at 1/100 dilution + HL60 cell lysate

Anti-EDG4 antibody - ab13028 from Abcam

Prices $359.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-EDG4 antibody - C-terminal - ab198897 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling EDG4 with ab198897 at 1/40 dilution.

Anti-EDG4 antibody - C-terminal - ab135980 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-EDG4 antibody - C-terminal (ab135980) at 1/500 dilution + COLO205 cell lysate at 30 µg

Anti-LPAR2 / EDG4 Antibody (aa1-33) - LS-C184845 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-LPAR2 / EDG4 Antibody (aa10-40, AP) - LS-C256492 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR2 / EDG4 Antibody (aa10-40, APC) - LS-C256494 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR2 / EDG4 Antibody (aa10-40, Biotin) - LS-C256495 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR2 / EDG4 Antibody (aa10-40, FITC) - LS-C256496 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR2 / EDG4 Antibody (aa10-40, Azide-free, HRP) - LS-C256498 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR2 / EDG4 Antibody (aa281-330) - LS-C291901 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LPAR2 / EDG4 Antibody (aa10-40, PE) - LS-C256499 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR2 / EDG4 Antibody (aa261-310) - LS-C291920 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LPAR2 / EDG4 Antibody (aa10-40) - LS-C321017 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPAR2 / EDG4 Antibody (Gln330) - LS-C177142 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of EDG-4 (Q330) pAb in extracts from COLO205 cells.

Anti-LPAR2 / EDG4 Antibody (aa271-320) - LS-C120644 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of MCF7 cells, using EDG4 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-LPAR2 / EDG4 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A3759 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-LPAR2 / EDG4 Antibody (aa290-339) - LS-C120576 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using EDG4 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-LPAR2 / EDG4 Antibody (aa18-32) IHC-plus™ - LS-B512 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LPAR2 / EDG4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B512 concentration 10 ug/ml.

Anti-LPAR2 / EDG4 Antibody (aa3-32) - LS-C100388 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

LPAR2/LPA2/EDG-4 Antibody - AF6396 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal

LPAR2/LPA2/EDG-4 Antibody - NLS1017 from Novus Biologicals

Prices $329.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: LPAR2/LPA2/EDG-4 Antibody [NLS1017] - Anti-LPAR3 / LPA3 / EDG7 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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