| Gene Symbol |
LPAR2
|
| Entrez Gene |
9170
|
| Alt Symbol |
EDG-4, EDG4, LPA-2, LPA2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysophosphatidic acid receptor 2
|
| Other Description |
G protein-coupled receptor|LPA receptor 2|LPA receptor EDG4|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4|lysophosphatidic acid receptor EDG4|lysophosphatidic acid receptor Edg-4
|
| Swissprots |
O00543 O43431 Q9HBW0
|
| Accessions |
AAB61528 CCQ43276 CCV20022 EAW84836 EAW84837 Q9HBW0 AF011466 AAC27728 AF197929 AAG28521 AF233092 AAF43409 AK123043 BAG53861 AK316573 BAG38162 AU133824 AY322548 AAP84361 BC025695 AAH25695 BM840024 XM_011528417 XP_011526719 XM_011528418 XP_011526720 XM_011528419 XP_011526721 XM_011528420 XP_011526722 XM_011528421 XP_011526723 NM_004720 NP_004711
|
| Function |
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. {ECO:0000269|PubMed:15143197, ECO:0000269|PubMed:19306925}.
|
| Subcellular Location |
Cell surface {ECO:0000269|PubMed:19306925}. Cell membrane {ECO:0000269|PubMed:19306925}; Multi-pass membrane protein {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
|
| Tissue Specificity |
Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.
|
| Top Pathways |
PI3K-Akt signaling pathway, Rap1 signaling pathway, Neuroactive ligand-receptor interaction
|