LPAR2

Gene Symbol LPAR2
Entrez Gene 9170
Alt Symbol EDG-4, EDG4, LPA-2, LPA2
Species Human
Gene Type protein-coding
Description lysophosphatidic acid receptor 2
Other Description G protein-coupled receptor|LPA receptor 2|LPA receptor EDG4|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4|lysophosphatidic acid receptor EDG4|lysophosphatidic acid receptor Edg-4
Swissprots O00543 O43431 Q9HBW0
Accessions AAB61528 CCQ43276 CCV20022 EAW84836 EAW84837 Q9HBW0 AF011466 AAC27728 AF197929 AAG28521 AF233092 AAF43409 AK123043 BAG53861 AK316573 BAG38162 AU133824 AY322548 AAP84361 BC025695 AAH25695 BM840024 XM_011528417 XP_011526719 XM_011528418 XP_011526720 XM_011528419 XP_011526721 XM_011528420 XP_011526722 XM_011528421 XP_011526723 NM_004720 NP_004711
Function Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. {ECO:0000269|PubMed:15143197, ECO:0000269|PubMed:19306925}.
Subcellular Location Cell surface {ECO:0000269|PubMed:19306925}. Cell membrane {ECO:0000269|PubMed:19306925}; Multi-pass membrane protein {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
Tissue Specificity Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.
Top Pathways PI3K-Akt signaling pathway, Rap1 signaling pathway, Neuroactive ligand-receptor interaction

EDG-4 CRISPR/Cas9 KO Plasmid (h) - sc-402448 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDG-4 HDR Plasmid (h) - sc-402448-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDG-4 Double Nickase Plasmid (h) - sc-402448-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDG-4 Double Nickase Plasmid (h2) - sc-402448-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDG-4 CRISPR Activation Plasmid (h) - sc-402448-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDG-4 CRISPR Activation Plasmid (h2) - sc-402448-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDG-4 Lentiviral Activation Particles (h) - sc-402448-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDG-4 Lentiviral Activation Particles (h2) - sc-402448-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EDG-4 siRNA (h) - sc-39926 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EDG-4 shRNA Plasmid (h) - sc-39926-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EDG-4 shRNA (h) Lentiviral Particles - sc-39926-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU093851 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12642 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12642 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04497 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04497

LPAR2 siRNA (Human) - CRH6068 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LPAR2/LPA2/EDG-4 RNAi - H00009170-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Human LPAR2 siRNA - orb266570 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LPAR2 shRNA Plasmid (Human) - CHH6068 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LPAR2 miRNA 3'UTR clone - MiUTR3H-07382 from Creative biogene

Species Reactivities Human
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