NOD2

Gene Symbol	NOD2
Entrez Gene	64127
Alt Symbol	ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
Species	Human
Gene Type	protein-coding
Description	nucleotide-binding oligomerization domain containing 2
Other Description	NLR family, CARD domain containing 2|NOD-like receptor C2|caspase recruitment domain family, member 15|caspase recruitment domain protein 15|caspase recruitment domain-containing protein 15|inflammatory bowel disease protein 1|nucleotide-binding oligomerization domain 2|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2|nucleotide-binding oligomerization domain-containing protein 2
Swissprots	Q9HC29 E2JEQ6 Q96RH8 Q96RH5 Q96RH6
Accessions	AAK70863 AAK70864 AAK70865 AAK70866 AAK70867 AAK70868 ABI96990 ABN42698 ABS17610 ABS17611 ABS17612 ACF33179 ACF95817 ACF95818 ACF95819 ACF95820 BAJ13469 BAJ13470 CAC42117 CAD10212 CAD10248 CBJ18719 EAW82767 Q9HC29 AF178930 AAG33677 AK298099 BAG60384 AY187233 AY187234 AY187235 AY187236 AY187237 AY187238 AY187239 AY187240 AY187241 AY187242 AY187243 AY187244 AY187245 AY187246 AY423901 AAQ93806 BC152737 AAI52738 BC156571 AAI56572 DQ868973 ABJ16061 HG508052 HQ204571 ADN95581 HY272594 XM_005256084 XP_005256141 XM_006721242 XP_006721305 XM_006721243 XP_006721306 XM_011523257 XP_011521559 XM_011523258 XP_011521560 XM_011523259 XP_011521561 XM_011523260 XP_011521562 XM_011523261 XP_011521563 XR_429725 XR_429726 XR_933387 NM_001293557 NP_001280486 NM_022162 NP_071445
Function	Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor- interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response. {ECO:0000269|PubMed:23806334}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Monocytes-specific.
Top Pathways	NOD-like receptor signaling pathway, Tuberculosis, TNF signaling pathway, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), Human, ELISA Kit - CSB-EL015915HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

NOD2 (Human) IP-WB Antibody Pair - H00064127-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

nucleotide-binding oligomerization domain containing 2, ELISA Kit - MBS939010 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Nucleotide-binding oligomerization domain-containing protein 2(NOD2) ELISA kit - CSB-EL015915HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

ELISA Kit for Nucleotide Binding Oligomerization Domain Containing Protein 2 (NOD2) - SEK295Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

CLIA Kit for Nucleotide Binding Oligomerization Domain Containing Protein 2 (NOD2) - SCK295Hu from Uscn Life Science Inc. Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 17.4pg/mL. Range 41.15-30000pg/mL The standard curve concentrations used for the CLIA’s were 30000pg/mL, 10000pg/mL, 3333.33pg/mL, 1111.11pg/mL, 370.37pg/mL, 123.46pg/mL, 41.15pg/mL

Human NOD2 ELISA Kit - E027146 from Biobool Category ELISA Kit Sensitivity 0.055ng/mL.

NOD2 ELISA Kit (Human) (OKCD02031) - OKCD02031 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.055 ng/mL Range 0.156 - 10 ng/mL

anti-CARD15 / NOD2 antibody - ARG56508 from Arigo Biolaboratories Category ELISA Kit

anti-CARD15 / NOD2 antibody - ARG64062 from Arigo Biolaboratories Category ELISA Kit

Nucleotide Binding Oligomerization Domain Containing Protein 2, ELISA Kit - MBS2031985 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.055ng/mL. Range 0.156-10ng/mL. The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.312ng/mL, 0.156ng/mL.

Nucleotide Binding Oligomerization Domain Containing Protein 2, CLIA Kit - MBS2031858 from MyBioSource Category CLIA Kit Prices $440.00, $655.00, $900.00, $3,705.00, $6,680.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 17.4pg/mL. Range 41.2-30,000pg/mL. The standard curve concentrations used for the CLIA's were 30,000pg/mL, 10,000pg/mL, 3,333.3pg/mL, 1,111.1pg/mL, 370.4pg/mL, 123.5pg/mL, 41.2pg/mL.

NOD2 ELISA Kit (Human) (OKCA02128) - OKCA02128 from Aviva Systems Biology Category ELISA Kit Sensitivity 6.25 pg/mL Range 25 pg/mL-1,600 pg/mL

NOD2 Chemi-Luminescent ELISA Kit (Human) (OKCD03832) - OKCD03832 from Aviva Systems Biology Category ELISA Kit Sensitivity 0.0412 ng/mL Range 0.0412 - 30 ng/mL

Human NOD2 / CARD15 ELISA Kit (Sandwich ELISA) - LS-F39628 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.055 Range 41.2-30000 pg/ml

Human NOD2 / CARD15 ELISA Kit (CLIA) - LS-F38861 from LifeSpan Bioscience Category ELISA Kit Sensitivity 17.4 Range 41.2-30000 pg/ml

Human NOD2 ELISA Kit - orb404965 from Biorbyt Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

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