| Gene Symbol | NOD2 |
|---|---|
| Entrez Gene | 64127 |
| Alt Symbol | ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nucleotide-binding oligomerization domain containing 2 |
| Other Description | NLR family, CARD domain containing 2|NOD-like receptor C2|caspase recruitment domain family, member 15|caspase recruitment domain protein 15|caspase recruitment domain-containing protein 15|inflammatory bowel disease protein 1|nucleotide-binding oligomerization domain 2|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2|nucleotide-binding oligomerization domain-containing protein 2 |
| Swissprots | Q9HC29 E2JEQ6 Q96RH8 Q96RH5 Q96RH6 |
| Accessions | AAK70863 AAK70864 AAK70865 AAK70866 AAK70867 AAK70868 ABI96990 ABN42698 ABS17610 ABS17611 ABS17612 ACF33179 ACF95817 ACF95818 ACF95819 ACF95820 BAJ13469 BAJ13470 CAC42117 CAD10212 CAD10248 CBJ18719 EAW82767 Q9HC29 AF178930 AAG33677 AK298099 BAG60384 AY187233 AY187234 AY187235 AY187236 AY187237 AY187238 AY187239 AY187240 AY187241 AY187242 AY187243 AY187244 AY187245 AY187246 AY423901 AAQ93806 BC152737 AAI52738 BC156571 AAI56572 DQ868973 ABJ16061 HG508052 HQ204571 ADN95581 HY272594 XM_005256084 XP_005256141 XM_006721242 XP_006721305 XM_006721243 XP_006721306 XM_011523257 XP_011521559 XM_011523258 XP_011521560 XM_011523259 XP_011521561 XM_011523260 XP_011521562 XM_011523261 XP_011521563 XR_429725 XR_429726 XR_933387 NM_001293557 NP_001280486 NM_022162 NP_071445 |
| Function | Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor- interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response. {ECO:0000269|PubMed:23806334}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Monocytes-specific. |
| Top Pathways | NOD-like receptor signaling pathway, Tuberculosis, TNF signaling pathway, Inflammatory bowel disease (IBD) |
NOD2 CRISPR/Cas9 KO Plasmid (h) - sc-400668 from Santa Cruz Biotechnology
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NOD2 HDR Plasmid (h) - sc-400668-HDR from Santa Cruz Biotechnology
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NOD2 Double Nickase Plasmid (h) - sc-400668-NIC from Santa Cruz Biotechnology
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NOD2 Double Nickase Plasmid (h2) - sc-400668-NIC-2 from Santa Cruz Biotechnology
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NOD2 CRISPR Activation Plasmid (h) - sc-400668-ACT from Santa Cruz Biotechnology
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NOD2 CRISPR Activation Plasmid (h2) - sc-400668-ACT-2 from Santa Cruz Biotechnology
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NOD2 Lentiviral Activation Particles (h) - sc-400668-LAC from Santa Cruz Biotechnology
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NOD2 Lentiviral Activation Particles (h2) - sc-400668-LAC-2 from Santa Cruz Biotechnology
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NOD2 siRNA (h) - sc-43973 from Santa Cruz Biotechnology
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NOD2 shRNA Plasmid (h) - sc-43973-SH from Santa Cruz Biotechnology
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NOD2 shRNA (h) Lentiviral Particles - sc-43973-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU033731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2486 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2486 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08742 from Sigma-Aldrich
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NOD2 siRNA (Human) - CRJ1936 from Cohesion Biosciences
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shRNA set against Human NOD2 (NM_022162.1) - SHH353452 from Creative biogene
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shRNA set against Human NOD2(NM_022162.1) - SHR015150 from Creative biogene
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Human NOD2 siRNA - orb272437 from Biorbyt
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NOD2 shRNA Plasmid (Human) - CHJ1936 from Cohesion Biosciences
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NOD2 miRNA 3'UTR clone - MiUTR1H-06832 from Creative biogene
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