NOD2

Gene Symbol NOD2
Entrez Gene 64127
Alt Symbol ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
Species Human
Gene Type protein-coding
Description nucleotide-binding oligomerization domain containing 2
Other Description NLR family, CARD domain containing 2|NOD-like receptor C2|caspase recruitment domain family, member 15|caspase recruitment domain protein 15|caspase recruitment domain-containing protein 15|inflammatory bowel disease protein 1|nucleotide-binding oligomerization domain 2|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2|nucleotide-binding oligomerization domain-containing protein 2
Swissprots Q9HC29 E2JEQ6 Q96RH8 Q96RH5 Q96RH6
Accessions AAK70863 AAK70864 AAK70865 AAK70866 AAK70867 AAK70868 ABI96990 ABN42698 ABS17610 ABS17611 ABS17612 ACF33179 ACF95817 ACF95818 ACF95819 ACF95820 BAJ13469 BAJ13470 CAC42117 CAD10212 CAD10248 CBJ18719 EAW82767 Q9HC29 AF178930 AAG33677 AK298099 BAG60384 AY187233 AY187234 AY187235 AY187236 AY187237 AY187238 AY187239 AY187240 AY187241 AY187242 AY187243 AY187244 AY187245 AY187246 AY423901 AAQ93806 BC152737 AAI52738 BC156571 AAI56572 DQ868973 ABJ16061 HG508052 HQ204571 ADN95581 HY272594 XM_005256084 XP_005256141 XM_006721242 XP_006721305 XM_006721243 XP_006721306 XM_011523257 XP_011521559 XM_011523258 XP_011521560 XM_011523259 XP_011521561 XM_011523260 XP_011521562 XM_011523261 XP_011521563 XR_429725 XR_429726 XR_933387 NM_001293557 NP_001280486 NM_022162 NP_071445
Function Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor- interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response. {ECO:0000269|PubMed:23806334}.
Subcellular Location Cytoplasm.
Tissue Specificity Monocytes-specific.
Top Pathways NOD-like receptor signaling pathway, Tuberculosis, TNF signaling pathway, Inflammatory bowel disease (IBD)

NOD2 (H-300) - sc-30199 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NOD2 (H-300): sc-30199. Western blot analysis of NOD2 expression in RAW 264.7 whole cell lysate.

NOD2 (P-18) - sc-23587 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NOD2 (P-18): sc-23587. Western blot analysis of human recombinant NOD2 fusion protein.

NOD2 (2D9) - sc-56168 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-CARD15 antibody - ab188646 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded Human small intestine sections labeling CARD15 using ab188646 at 3 µg/ml.

Anti-CARD15 antibody - ab115542 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115542, at 3µg/ml, staining CARD15 in Formalin-fixed, Paraffin-embedded Human Small intestine tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-CARD15 antibody - ab172755 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-CARD15 antibody (ab172755) at 1 µg/mlLane 1 : CARD15-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-CARD15 antibody [2D9] - ab31488 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D9
Anti-CARD15 antibody [2D9] (ab31488) at 2 µg/ml + HEK 293 overexpressing CARD15 at 20 µgSecondaryGoat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CARD15 antibody [EPR16252] - ab197030 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16252
All lanes : Anti-CARD15 antibody [EPR16252] (ab197030) at 1/5000 dilutionLane 1 : Caco-2 (Human colorectal adenocarcinoma cells) whole cell lysateLane 2 : Jurkat (Human T cell leukemia cells from peripheral blood) whole cell lysateLane 3 : HT-29 (Human colorectal adenocarcinoma cells) whole cell lysateLane 4 : HeLa (Human epithelial cells from cervix adenocarcinoma) whole cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-CARD15 antibody - ab36836 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CARD15 antibody (ab36836) at 2 µg/ml + HeLa cell lysate

Anti-CARD15 antibody - ab53518 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-CARD15 antibody (ab53518) at 0.1 µg/ml + Human Peripheral Blood Mononucleocyte lysate (35µg protein in RIPA buffer).

Anti-NOD2 / CARD15 Antibody (N-Terminus) IHC-plus™ - LS-B2720 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NOD2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2720 concentration 3 ug/ml.

Anti-NOD2 / CARD15 Antibody - LS-C9335 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NOD2 / CARD15 Antibody (N-Terminus) - LS-C9336 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NOD2 / CARD15 Antibody (aa28-301) - LS-C16914 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-NOD2 / CARD15 Antibody (aa28-301) - LS-C73659 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-NOD2 / CARD15 Antibody (C-Terminus) - LS-C73661 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NOD2 / CARD15 Antibody (C-Terminus) - LS-C131076 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NOD2 / CARD15 Antibody (aa1000-1040) - LS-C2581 from LifeSpan Bioscience

Prices $335.00
Sizes 87 µg
Host Rabbit
Clonality Polyclonal
Detection of NOD2 in 20 ug of NOD2 transfected 293T cell lysate. ECL detection in 15 seconds.

Anti-NOD2 / CARD15 Antibody (aa28-301, clone 2D9, DY550) - LS-C141157 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D9

Anti-NOD2 / CARD15 Antibody (aa28-301, clone 2D9, Biotin) - LS-C141210 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D9

Anti-NOD2 / CARD15 Antibody (aa385-399) - LS-C54608 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-NOD2 / CARD15 Antibody (aa28-301, clone 2D9, DY650) - LS-C141211 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D9

Anti-NOD2 / CARD15 Antibody (clone NOD-15) - LS-C40849 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone NOD-15
Cell extract from MCF-7 cells transfected with either human Nod1 (Lane 1) or human Nod2 (Lane 2) was resolved by electrophoresis, transferred to nitrocellulose, and probed with monoclonal anti-Nod2 antibody (clone NOD-15). Proteins were visualized using a

Anti-NOD2 / CARD15 Antibody (aa28-301, clone 2D9, DY488) - LS-C141212 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D9

Anti-NOD2 / CARD15 Antibody (aa28-301, clone 2D9, HRP) - LS-C141213 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D9
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