SMC3

Gene Symbol	SMC3
Entrez Gene	9126
Alt Symbol	BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1
Species	Human
Gene Type	protein-coding
Description	structural maintenance of chromosomes 3
Other Description	SMC protein 3|basement membrane-associated chondroitin proteoglycan|chondroitin sulfate proteoglycan 6 (bamacan)|chromosome-associated polypeptide|structural maintenance of chromosomes protein 3
Swissprots	Q5T482 O60464 A8K156 Q9UQE7
Accessions	EAW49557 EAW49558 Q9UQE7 AF020043 AAC14893 AF067163 AAD32447 AJ005015 CAA06289 AK289771 BAF82460 AK315845 BAF98736 BC047324 AAH47324 CA439554 NM_005445 NP_005436
Function	Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}.
Subcellular Location	Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser- 1083 is preferentially associated with unsynapsed chromosomal regions (By similarity). {ECO:0000250}.
Top Pathways	Cell cycle, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SMC3 peptide - ab74580 from Abcam Category Peptide

Human SMC3 peptide - ab74581 from Abcam Category Peptide

SMC3 / HCAP Antibody Blocking Peptide - LS-E3633 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMC3 / HCAP Antibody Blocking Peptide - LS-E17251 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMC3 / HCAP Antibody Blocking Peptide - LS-E17250 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SMC3 Protein - H00009126-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SMC3-Antibody-Center-Blocking-Peptide - BP14836c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Bim peptide - GTX27887 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

TMEM150A Protein Lysate (APL10560) - APL10560 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

BCL2L11 protein (His tag) - 80R-2404 from Fitzgerald Category Protein Prices $270.00 Sizes 50 µg Source E.coli

HCAP (pS1083) Blocking Peptide - abx161128 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken

Human SMC3 Protein - abx069182 from Abbexa Category Protein Source E.coli Species Human

Bamacan - H00009126-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Bamacan - H00009126-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SMC3 fusion protein - Ag6174 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SMC3 fusion protein - ag5440 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

BLMH Human - ENPS-025 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human SMC3, His-tagged - SMC3-31196TH from Creative Biomart Category Protein Source E. coli

Recombinant Human SMC3, His-tagged - SMC3-2810H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human SMC3, GST-tagged - SMC3-20H from Creative Biomart Category Protein Source Wheat germ Species Human

BLMH - JNV-054 from Reagent Proteins Category Protein Prices $364.00, $2,898.00 Sizes 20.00 µg, 1 mg Source E. coli

Recombinant Structural Maintenance Of Chromosomes Protein 3 (SMC3) - RPB146Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

HCAP (pS1083) Blocking Peptide - CBP3627 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine

Recombinant Dermcidin (DCD) - RPC896Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Structural Maintenance Of Chromosomes Protein 3 (SMC3) - RPB146Hu01 from Cloud-clone Category Protein Source E.coli Species Human

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