| Gene Symbol |
OTULIN
|
| Entrez Gene |
90268
|
| Alt Symbol |
FAM105B, GUM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
OTU deubiquitinase with linear linkage specificity
|
| Other Description |
OTU domain-containing deubiquitinase with linear linkage specificity|deubiquitinating enzyme otulin|family with sequence similarity 105, member B|gumby|protein FAM105B|ubiquitin thioesterase Gumby|ubiquitin thioesterase otulin
|
| Swissprots |
Q96BN8 D3DTD3 Q96IA3 Q8NAS0
|
| Accessions |
EAX08037 EAX08038 EAX08039 Q96BN8 AK092203 BAC03828 AK095615 AK123480 BC007706 AAH07706 BC015392 AAH15392 CK817982 XM_011514151 XP_011512453 XM_011514152 XP_011512454 XM_011514153 XP_011512455 XM_011514154 XP_011512456 NM_138348 NP_612357
|
| Function |
Deubiquitinase that specifically removes linear ('Met- 1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling. {ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:23806334, ECO:0000269|PubMed:23827681}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:23746843}.
|