OTULIN

Gene Symbol	OTULIN
Entrez Gene	90268
Alt Symbol	FAM105B, GUM
Species	Human
Gene Type	protein-coding
Description	OTU deubiquitinase with linear linkage specificity
Other Description	OTU domain-containing deubiquitinase with linear linkage specificity|deubiquitinating enzyme otulin|family with sequence similarity 105, member B|gumby|protein FAM105B|ubiquitin thioesterase Gumby|ubiquitin thioesterase otulin
Swissprots	Q96BN8 D3DTD3 Q96IA3 Q8NAS0
Accessions	EAX08037 EAX08038 EAX08039 Q96BN8 AK092203 BAC03828 AK095615 AK123480 BC007706 AAH07706 BC015392 AAH15392 CK817982 XM_011514151 XP_011512453 XM_011514152 XP_011512454 XM_011514153 XP_011512455 XM_011514154 XP_011512456 NM_138348 NP_612357
Function	Deubiquitinase that specifically removes linear ('Met- 1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling. {ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:23806334, ECO:0000269|PubMed:23827681}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:23746843}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® OTULIN siRNA I - 14132 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

FAM105B CRISPR/Cas9 KO Plasmid (h) - sc-407676 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FAM105B HDR Plasmid (h) - sc-407676-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FAM105B Double Nickase Plasmid (h) - sc-407676-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FAM105B Double Nickase Plasmid (h2) - sc-407676-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FAM105B CRISPR Activation Plasmid (h) - sc-407676-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FAM105B CRISPR Activation Plasmid (h2) - sc-407676-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FAM105B Lentiviral Activation Particles (h) - sc-407676-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FAM105B Lentiviral Activation Particles (h2) - sc-407676-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FAM105B siRNA (h) - sc-91772 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FAM105B shRNA Plasmid (h) - sc-91772-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FAM105B shRNA (h) Lentiviral Particles - sc-91772-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU042841 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8113 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8113 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

FAM105B siRNA (Human) - CRJ3920 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FAM105B - MBS8206477 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human FAM105B (NM_138348.4) - SHH288961 from Creative biogene Category siRNA Species Reactivities Human

Human FAM105B siRNA - orb274421 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FAM105B shRNA Plasmid (Human) - CHJ3920 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

FAM105B miRNA 3'UTR clone - MiUTR1H-03389 from Creative biogene Species Reactivities Human

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