OTULIN

Gene Symbol	OTULIN
Entrez Gene	90268
Alt Symbol	FAM105B, GUM
Species	Human
Gene Type	protein-coding
Description	OTU deubiquitinase with linear linkage specificity
Other Description	OTU domain-containing deubiquitinase with linear linkage specificity|deubiquitinating enzyme otulin|family with sequence similarity 105, member B|gumby|protein FAM105B|ubiquitin thioesterase Gumby|ubiquitin thioesterase otulin
Swissprots	Q96BN8 D3DTD3 Q96IA3 Q8NAS0
Accessions	EAX08037 EAX08038 EAX08039 Q96BN8 AK092203 BAC03828 AK095615 AK123480 BC007706 AAH07706 BC015392 AAH15392 CK817982 XM_011514151 XP_011512453 XM_011514152 XP_011512454 XM_011514153 XP_011512455 XM_011514154 XP_011512456 NM_138348 NP_612357
Function	Deubiquitinase that specifically removes linear ('Met- 1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling. {ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:23806334, ECO:0000269|PubMed:23827681}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:23746843}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Human FAM105B/OTULIN, CF - ab188694 from Abcam Source E. coli Species Human

OTULIN / FAM105B Antibody Blocking Peptide - LS-E7954 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FAM105B-Antibody-Center-Blocking-peptide - BP5734c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human FAM105B/OTULIN, CF - E-558-050 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human Protein FAM105B(FAM105B) - CSB-YP853391HU CSB-EP853391HU CSB-BP853391HU CSB-MP853391HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human FAM105B/OTULIN Protein, CF - E-558 from R&D Systems Category Protein Prices $169.00 Sizes 50 µg Source E. coli -derived Species Human

FAM105B/OTULIN - E-558 from Boston Biochem Prices $169.00 Sizes 50 µg

FAM105B/OTULIN Recombinant Protein Antigen - NBP2-14722PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

FAM105B Peptide, Human - M34GP05218H from Creative Peptides Category Peptide Source Synthetic. Species Human

FAM105B fusion protein - Ag22302 from Proteintech Group Category Protein Source E. coli -derived, PET30a Species Human

Protein FAM105B (FAM105B), Recombinant Protein - MBS1434981 from MyBioSource Category Protein Prices $1,115.00, $1,115.00, $1,345.00, $1,345.00, $1,770.00, $1,770.00, $2,235.00, $2,235.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human OTULIN Protein, GST-tagged - OTULIN-3666H from Creative Biomart Category Protein Source Wheat Germ Species Human

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