| Gene Symbol |
RDH16
|
| Entrez Gene |
8608
|
| Alt Symbol |
RODH-4, SDR9C8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinol dehydrogenase 16 (all-trans)
|
| Other Description |
microsomal NAD(+)-dependent retinol dehydrogenase 4|microsomal NAD+-dependent retinol dehydrogenase 4|retinol dehydrogenase 16|retinol dehydrogenase 16 (all-trans and 13-cis)|short chain dehydrogenase/reductase family 9C member 8|short chain dehydrogenase/reductase family 9C, member 8|sterol/retinol dehydrogenase
|
| Swissprots |
O75452 Q9UNV2
|
| Accessions |
EAW96968 O75452 AB209332 BAD92569 AF057034 AAC39922 AF086735 AAC72923 AK311025 AW449664 BC160081 AAI60081 DQ499468 ABF51671 XM_005269205 XP_005269262 XM_011538923 XP_011537225 XM_011538924 XP_011537226 NM_003708 NP_003699
|
| Function |
Oxidoreductase with a preference for NAD. Oxidizes all- trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction. {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:12534290, ECO:0000269|PubMed:9677409}.
|
| Subcellular Location |
Microsome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in adult liver (at protein level). Detected in endometrium, liver and foreskin. Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers. Detected in fetal liver and lung. {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:11967490, ECO:0000269|PubMed:9677409}.
|
| Top Pathways |
Retinol metabolism
|