RDH16
| Gene Symbol | RDH16 |
|---|---|
| Entrez Gene | 8608 |
| Alt Symbol | RODH-4, SDR9C8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | retinol dehydrogenase 16 (all-trans) |
| Other Description | microsomal NAD(+)-dependent retinol dehydrogenase 4|microsomal NAD+-dependent retinol dehydrogenase 4|retinol dehydrogenase 16|retinol dehydrogenase 16 (all-trans and 13-cis)|short chain dehydrogenase/reductase family 9C member 8|short chain dehydrogenase/reductase family 9C, member 8|sterol/retinol dehydrogenase |
| Swissprots | O75452 Q9UNV2 |
| Accessions | EAW96968 O75452 AB209332 BAD92569 AF057034 AAC39922 AF086735 AAC72923 AK311025 AW449664 BC160081 AAI60081 DQ499468 ABF51671 XM_005269205 XP_005269262 XM_011538923 XP_011537225 XM_011538924 XP_011537226 NM_003708 NP_003699 |
| Function | Oxidoreductase with a preference for NAD. Oxidizes all- trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction. {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:12534290, ECO:0000269|PubMed:9677409}. |
| Subcellular Location | Microsome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. |
| Tissue Specificity | Highly expressed in adult liver (at protein level). Detected in endometrium, liver and foreskin. Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers. Detected in fetal liver and lung. {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:11967490, ECO:0000269|PubMed:9677409}. |
| Top Pathways | Retinol metabolism |
RDH16 CRISPR/Cas9 KO Plasmid (h) - sc-411192 from Santa Cruz Biotechnology
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RDH16 HDR Plasmid (h) - sc-411192-HDR from Santa Cruz Biotechnology
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RDH16 Double Nickase Plasmid (h) - sc-411192-NIC from Santa Cruz Biotechnology
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RDH16 Double Nickase Plasmid (h2) - sc-411192-NIC-2 from Santa Cruz Biotechnology
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RDH16 CRISPR Activation Plasmid (h) - sc-411192-ACT from Santa Cruz Biotechnology
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RDH16 CRISPR Activation Plasmid (h2) - sc-411192-ACT-2 from Santa Cruz Biotechnology
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RDH16 Lentiviral Activation Particles (h) - sc-411192-LAC from Santa Cruz Biotechnology
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RDH16 Lentiviral Activation Particles (h2) - sc-411192-LAC-2 from Santa Cruz Biotechnology
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RDH16 siRNA (h) - sc-95898 from Santa Cruz Biotechnology
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RDH16 shRNA Plasmid (h) - sc-95898-SH from Santa Cruz Biotechnology
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RDH16 shRNA (h) Lentiviral Particles - sc-95898-V from Santa Cruz Biotechnology
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RDH16 RNAi - H00008608-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN18114 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18114 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05399 from Sigma-Aldrich
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RDH16 siRNA (Human) - CRH5655 from Cohesion Biosciences
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RDH16 - MBS8237135 from MyBioSource
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shRNA set against Human Rdh1 (NM_003708.3) - SHH391428 from Creative biogene
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shRNA set against Human RDH16(NM_003708.3) - SHR173992 from Creative biogene
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Human RDH16 siRNA - orb266157 from Biorbyt
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RDH16 shRNA Plasmid (Human) - CHH5655 from Cohesion Biosciences
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RDH16 miRNA 3'UTR clone - MiUTR1H-08719 from Creative biogene
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