Gene Symbol | RDH16 |
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Entrez Gene | 8608 |
Alt Symbol | RODH-4, SDR9C8 |
Species | Human |
Gene Type | protein-coding |
Description | retinol dehydrogenase 16 (all-trans) |
Other Description | microsomal NAD(+)-dependent retinol dehydrogenase 4|microsomal NAD+-dependent retinol dehydrogenase 4|retinol dehydrogenase 16|retinol dehydrogenase 16 (all-trans and 13-cis)|short chain dehydrogenase/reductase family 9C member 8|short chain dehydrogenase/reductase family 9C, member 8|sterol/retinol dehydrogenase |
Swissprots | O75452 Q9UNV2 |
Accessions | EAW96968 O75452 AB209332 BAD92569 AF057034 AAC39922 AF086735 AAC72923 AK311025 AW449664 BC160081 AAI60081 DQ499468 ABF51671 XM_005269205 XP_005269262 XM_011538923 XP_011537225 XM_011538924 XP_011537226 NM_003708 NP_003699 |
Function | Oxidoreductase with a preference for NAD. Oxidizes all- trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction. {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:12534290, ECO:0000269|PubMed:9677409}. |
Subcellular Location | Microsome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. |
Tissue Specificity | Highly expressed in adult liver (at protein level). Detected in endometrium, liver and foreskin. Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers. Detected in fetal liver and lung. {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:11967490, ECO:0000269|PubMed:9677409}. |
Top Pathways | Retinol metabolism |
RDH16 (S-14) - sc-169127 from Santa Cruz Biotechnology
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Anti-Retinol dehydrogenase 16 antibody - ab89653 from Abcam
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Anti-Retinol dehydrogenase 16 antibody - ab84344 from Abcam
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Anti-Retinol dehydrogenase 16 antibody - ab169667 from Abcam
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Anti-RDH16 Antibody (aa3-31) - LS-C162525 from LifeSpan Bioscience
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Anti-RDH16 Antibody (Internal) - LS-C145067 from LifeSpan Bioscience
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Anti-RDH16 Antibody (aa3-31, AP) - LS-C239892 from LifeSpan Bioscience
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Anti-RDH16 Antibody (aa3-31, FITC) - LS-C239894 from LifeSpan Bioscience
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Anti-RDH16 Antibody (aa3-31, APC) - LS-C239893 from LifeSpan Bioscience
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Anti-RDH16 Antibody (aa3-31, Biotin) - LS-C239895 from LifeSpan Bioscience
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Anti-RDH16 Antibody (aa3-31, PE) - LS-C239897 from LifeSpan Bioscience
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Anti-RDH16 Antibody (aa3-31, Azide-free, HRP) - LS-C248642 from LifeSpan Bioscience
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Anti-RDH16 Antibody (aa10-39) - LS-C324599 from LifeSpan Bioscience
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Anti-RDH16 Antibody (aa215-264) - LS-C116200 from LifeSpan Bioscience
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Anti-RDH16 Antibody (N-Terminus) - LS-C101945 from LifeSpan Bioscience
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RDH16 Antibody - NBP1-87117 from Novus Biologicals
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RDH16 Antibody - NBP1-58060 from Novus Biologicals
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RDH16 Antibody - NBP1-58059 from Novus Biologicals
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RDH16 Antibody - NBP1-30011 from Novus Biologicals
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RDH16 Antibody - H00008608-B01P-50ug from Novus Biologicals
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Anti-RDH16 antibody produced in rabbit - HPA038518 from Sigma-Aldrich
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Anti-RDH16 antibody produced in rabbit - SAB2101973 from Sigma-Aldrich
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Anti-RDH16 antibody produced in rabbit - SAB2105453 from Sigma-Aldrich
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RDH16 antibody - N-terminal region (ARP42141_P050) - ARP42141_P050 from Aviva Systems Biology
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RDH16 antibody - middle region (ARP42142_P050) - ARP42142_P050 from Aviva Systems Biology
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