CRTC1

Gene Symbol CRTC1
Entrez Gene 23373
Alt Symbol MECT1, TORC-1, TORC1, WAMTP1
Species Human
Gene Type protein-coding
Description CREB regulated transcription coactivator 1
Other Description CREB-regulated transcription coactivator 1|mucoepidermoid carcinoma translocated protein 1|transducer of regulated cAMP response element-binding protein (CREB) 1
Swissprots Q96AI8 Q7LDZ2 Q6Y3A3 Q8N6W3 O75114 Q8IZ34 Q6UUV9 Q9H801 A6NMG5 Q8IUL3 Q8IZL1
Accessions AAC97072 EAW84730 EAW84731 EAW84732 EAW84733 Q6UUV9 AB014516 BAA31591 AK024089 BAB14822 AU118537 AY040323 AAK93832 AY186998 AAP12463 AY360171 AAQ98856 BC017075 AAH17075 BC023614 AAH23614 BC028050 AAH28050 BM680095 DB355148 DQ893310 ABM84236 DQ894228 ABM85154 XM_005259833 XP_005259890 XM_005259834 XP_005259891 XM_005259835 XP_005259892 XM_005259836 XP_005259893 XM_006722710 XP_006722773 XM_011527842 XP_011526144 NM_025021 NM_001098482 NP_001091952 NM_015321 NP_056136
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated tra
Subcellular Location Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain. {ECO:0000250|UniProtKB:Q68ED7}.
Tissue Specificity Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. {ECO:0000269|PubMed:14720503, ECO:0000269|PubMed:16980408}.
Top Pathways HTLV-I infection

Phospho-TORC1/CRTC1 (Ser151) Antibody - 3359 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from U-87 MG cells, untransfected (-) or transfected with human wild-type (WT) TORC1 or TORC1 (Ser151Ala) (+), using Phospho-TORC1/CRTC1 (Ser151) Antibody (upper) or DYKDDDDK Tag Antibody #2368 (lower). DYKDDDDK-tagged WT and mutant Torc1 expression vectors were kindly provided by Dr. Marc Montminy at the Salk Institute for Biological Studies.

TORC1/CRTC1 (C71D11) Rabbit mAb - 2587 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C71D11
Western blot analysis of extracts from mouse and rat brain using TORC1/CRTC1 (C71D11) Rabbit mAb.

TORC1/CRTC1 Antibody - 2501 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of mouse brain extract using TORC1/CRTC1 Antibody.

TORC1 (A-1) - sc-271333 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TORC1 (A-1): sc-271333. Western blot analysis of TORC1 expression in Hep G2 nuclear extract.

TORC1 (B-12) - sc-390881 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TORC1 (B-12): sc-390881. Western blot analysis of TORC1 expression in non-transfected: sc-117752 (A) and human TORC1 transfected: sc-114714 (B) 293T whole cell lysates.

TORC1 (G-3) - sc-365009 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TORC1 (G-3): sc-365009. Western blot analysis of TORC1 expression in non-transfected: sc-117752 (A) and human TORC1 transfected: sc-114714 (B) 293T whole cell lysates.

TORC1 (H-125) - sc-67146 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TORC1 (H-125): sc-67146. Western blot analysis of TORC1 expression in non-transfected: sc-117752 (A) and human TORC1 transfected: sc-114714 (B) 293T whole cell lysates.

TORC1 (H-6) - sc-365010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TORC1 (H-6): sc-365010. Western blot analysis of TORC1 expression in non-transfected: sc-117752 (A) and human TORC1 transfected: sc-114714 (B) 293T whole cell lysates.

TORC1 (L-12) - sc-46269 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TORC1 (L-12): sc-46269. Western blot analysis of TORC1 expression in non-transfected: sc-117752 (A) and human TORC1 transfected: sc-114714 (B) 293T whole cell lysates.

TORC1 (N-14) - sc-46270 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TORC1 (N-14): sc-46270. Western blot analysis of TORC1 expression in HeLa (A), SW480 (B), A-431 (C), Jurkat (D) and RAW 264.7 (E) nuclear extracts.

Anti-TORC1 antibody - ab115330 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115330, at 1/500 dilution, staining MECT1 in Formalin-fixed, Paraffin-embedded Human Kidney tissue by Immunohistochemistry followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-TORC1 antibody - ab47256 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TORC1 antibody - ab114974 from Abcam

Prices $428.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab114974 at 1/250 dilution staining MECT1 in Formalin-fixed, Paraffin-embedded Human Lung carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

Anti-TORC1 antibody - ab181811 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TORC1 antibody - ab70823 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TORC1 antibody [1B5] - ab104841 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1B5
Anti-TORC1 antibody [1B5] (ab104841) at 1/500 dilution + MECT1-hIgGFc transfected HEK293 cell lysate

Anti-TORC1 antibody [4E7-C1-F9-E6] - ab176472 from Abcam

Host Mouse
Clonality Monoclonal
Clone 4E7-C1-F9-E6
Immunocytochemical staining of HeLa cells using anti-TORC1 antibody (ab176472)  at a dilution of 1:200. Cells fixed with 4% paraformaldehyde.

Anti-TORC1 antibody [EPR3381(2)] - ab109736 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3381(2)
All lanes : Anti-TORC1 antibody [EPR3381(2)] (ab109736) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : Human fetal brain lysateLane 3 : HeLa cell lysateLysates/proteins at 10 µg per lane.

Anti-TORC1 antibody [EPR3382] - ab92477 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3382
Overlay histogram showing SHSY-5Y cells stained with ab92477 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab92477, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SHSY-5Y cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-CRTC1 / MECT1 / TORC1 Antibody IHC-plus™ - LS-B11337 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Anti-CRTC1 / MECT1 / TORC1 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CRTC1 / MECT1 / TORC1 Antibody - LS-C39763 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRTC1 / MECT1 / TORC1 Antibody (C-Terminus) - LS-C90625 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRTC1 / MECT1 / TORC1 Antibody (aa384-471) - LS-C124695 from LifeSpan Bioscience

Host Rat
Clonality Monoclonal

Anti-CRTC1 / MECT1 / TORC1 Antibody (aa25-75) - LS-C286016 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRTC1 / MECT1 / TORC1 Antibody - LS-C342272 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
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