| Gene Symbol |
CRTC1
|
| Entrez Gene |
23373
|
| Alt Symbol |
MECT1, TORC-1, TORC1, WAMTP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CREB regulated transcription coactivator 1
|
| Other Description |
CREB-regulated transcription coactivator 1|mucoepidermoid carcinoma translocated protein 1|transducer of regulated cAMP response element-binding protein (CREB) 1
|
| Swissprots |
Q96AI8 Q7LDZ2 Q6Y3A3 Q8N6W3 O75114 Q8IZ34 Q6UUV9 Q9H801 A6NMG5 Q8IUL3 Q8IZL1
|
| Accessions |
AAC97072 EAW84730 EAW84731 EAW84732 EAW84733 Q6UUV9 AB014516 BAA31591 AK024089 BAB14822 AU118537 AY040323 AAK93832 AY186998 AAP12463 AY360171 AAQ98856 BC017075 AAH17075 BC023614 AAH23614 BC028050 AAH28050 BM680095 DB355148 DQ893310 ABM84236 DQ894228 ABM85154 XM_005259833 XP_005259890 XM_005259834 XP_005259891 XM_005259835 XP_005259892 XM_005259836 XP_005259893 XM_006722710 XP_006722773 XM_011527842 XP_011526144 NM_025021 NM_001098482 NP_001091952 NM_015321 NP_056136
|
| Function |
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated tra
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain. {ECO:0000250|UniProtKB:Q68ED7}.
|
| Tissue Specificity |
Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. {ECO:0000269|PubMed:14720503, ECO:0000269|PubMed:16980408}.
|
| Top Pathways |
HTLV-I infection
|
