CRTC1

Gene Symbol CRTC1
Entrez Gene 23373
Alt Symbol MECT1, TORC-1, TORC1, WAMTP1
Species Human
Gene Type protein-coding
Description CREB regulated transcription coactivator 1
Other Description CREB-regulated transcription coactivator 1|mucoepidermoid carcinoma translocated protein 1|transducer of regulated cAMP response element-binding protein (CREB) 1
Swissprots Q96AI8 Q7LDZ2 Q6Y3A3 Q8N6W3 O75114 Q8IZ34 Q6UUV9 Q9H801 A6NMG5 Q8IUL3 Q8IZL1
Accessions AAC97072 EAW84730 EAW84731 EAW84732 EAW84733 Q6UUV9 AB014516 BAA31591 AK024089 BAB14822 AU118537 AY040323 AAK93832 AY186998 AAP12463 AY360171 AAQ98856 BC017075 AAH17075 BC023614 AAH23614 BC028050 AAH28050 BM680095 DB355148 DQ893310 ABM84236 DQ894228 ABM85154 XM_005259833 XP_005259890 XM_005259834 XP_005259891 XM_005259835 XP_005259892 XM_005259836 XP_005259893 XM_006722710 XP_006722773 XM_011527842 XP_011526144 NM_025021 NM_001098482 NP_001091952 NM_015321 NP_056136
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated tra
Subcellular Location Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain. {ECO:0000250|UniProtKB:Q68ED7}.
Tissue Specificity Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. {ECO:0000269|PubMed:14720503, ECO:0000269|PubMed:16980408}.
Top Pathways HTLV-I infection

Human TORC1 protein fragment - ab153222 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153222 on a 12.5% SDS-PAGE stained with Coomassie Blue.

TORC1 Partial Recombinant Protein - H00023373-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

TORC1-Antibody-N-term-Blocking-Peptide - BP6968a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CRTC1-Antibody-N-term-Blocking-Peptide - BP9281a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CRTC1 / MECT1 - H00023373-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

CRTC1 / MECT1 - H00023373-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

TORC1 fusion protein - ag0693 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human CREB-regulated transcription coactivator 1(CRTC1) - CSB-YP757785HU CSB-EP757785HU CSB-BP757785HU CSB-MP757785HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CRTC1 / MECT1 (transcript variant 1) - TP306974 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
CRTC1 / MECT1

CRTC1 / MECT1 (transcript variant 3) - TP324693 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
CRTC1 / MECT1

TORC1 Recombinant Protein Antigen - NBP1-89865PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CRTC1 Peptide, Human - M34GP03665H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Recombinant CREB Regulated Transcription Coactivator 1 (CRTC1) - RPU50679 from Biomatik

Category Protein
Prices $182.00, $315.00, $482.00, $602.00
Sizes 10 µg, 50 µg, 100 µg, 200 µg
Source E.coli
Species Human

CREB Regulated Transcription Coactivator 1, Recombinant Protein - MBS2034595 from MyBioSource

Category Protein
Prices $160.00, $320.00, $495.00
Sizes 10 µg, 50 µg, 100 µg
Source E Coli Source: Prokaryotic expression
Species Human

CREB-regulated transcription coactivator 1 (CRTC1), Recombinant Protein - MBS1353754 from MyBioSource

Category Protein
Prices $1,430.00, $1,430.00, $1,660.00, $1,660.00, $2,425.00, $2,425.00, $2,870.00, $2,870.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

CRTC1, Recombinant Protein - MBS286181 from MyBioSource

Category Protein
Prices $345.00, $975.00, $1,345.00
Sizes 100 µg, 500 µg, 1 mg
Source E Coli
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