| Gene Symbol |
MKL1
|
| Entrez Gene |
57591
|
| Alt Symbol |
BSAC, MAL, MRTF-A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
megakaryoblastic leukemia (translocation) 1
|
| Other Description |
MKL/myocardin-like protein 1|Mkl1 variant 1 Mkl1_S|basic, SAP and coiled-coil domain|megakaryoblastic leukemia 1 protein|megakaryocytic acute leukemia protein|myocardin-related transcription factor A
|
| Swissprots |
Q96SC6 Q96SC5 Q8TCL1 Q969V6 Q9P2B0
|
| Accessions |
EAW60382 EAW60383 EAW60384 Q969V6 AB037859 BAA92676 AF368061 AAK54721 AF448806 AJ297257 CAC38826 AJ297258 CAC38827 AL713710 CAD28507 BC021586 BC064620 BC114364 AAI14365 BC115039 AAI15040 BC139730 BC141653 AAI41654 BC141655 AAI41656 BG716386 CR456522 CAG30408 CU013122 CAK54553 CU013410 CAK54852 HG764171 CDJ79779 HY058235 HY123688 XM_005261691 XP_005261748 XM_005261692 XP_005261749 XM_005261694 XP_005261751 XM_011530283 XP_011528585 XM_011530284 XP_011528586 XM_011530285 XP_011528587 XM_011530286 XP_011528588 XM_011530287 XP_011528589 NM_001282660 NP_001269589 NM_001282661 NP_001269590 NM_001282662 NP_001269591 NM_020831 NP_065882
|
| Function |
Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19350017, ECO:0000269|PubMed:24440334}. Cytoplasm {ECO:0000250}. Note=Binding to globular actin is required to maintain cytoplasmic localization. Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear globular actin, promoting retention of MKL1 in the nucleus and subsequent formation of an active complex with SRF (PubMed:24440334). {ECO:0000269|PubMed:24440334}.
|
| Tissue Specificity |
Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain.
|