MKL1

Gene Symbol	MKL1
Entrez Gene	57591
Alt Symbol	BSAC, MAL, MRTF-A
Species	Human
Gene Type	protein-coding
Description	megakaryoblastic leukemia (translocation) 1
Other Description	MKL/myocardin-like protein 1|Mkl1 variant 1 Mkl1_S|basic, SAP and coiled-coil domain|megakaryoblastic leukemia 1 protein|megakaryocytic acute leukemia protein|myocardin-related transcription factor A
Swissprots	Q96SC6 Q96SC5 Q8TCL1 Q969V6 Q9P2B0
Accessions	EAW60382 EAW60383 EAW60384 Q969V6 AB037859 BAA92676 AF368061 AAK54721 AF448806 AJ297257 CAC38826 AJ297258 CAC38827 AL713710 CAD28507 BC021586 BC064620 BC114364 AAI14365 BC115039 AAI15040 BC139730 BC141653 AAI41654 BC141655 AAI41656 BG716386 CR456522 CAG30408 CU013122 CAK54553 CU013410 CAK54852 HG764171 CDJ79779 HY058235 HY123688 XM_005261691 XP_005261748 XM_005261692 XP_005261749 XM_005261694 XP_005261751 XM_011530283 XP_011528585 XM_011530284 XP_011528586 XM_011530285 XP_011528587 XM_011530286 XP_011528588 XM_011530287 XP_011528589 NM_001282660 NP_001269589 NM_001282661 NP_001269590 NM_001282662 NP_001269591 NM_020831 NP_065882
Function	Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:19350017, ECO:0000269|PubMed:24440334}. Cytoplasm {ECO:0000250}. Note=Binding to globular actin is required to maintain cytoplasmic localization. Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear globular actin, promoting retention of MKL1 in the nucleus and subsequent formation of an active complex with SRF (PubMed:24440334). {ECO:0000269|PubMed:24440334}.
Tissue Specificity	Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BSAC / MKL1 Antibody Blocking Peptide - LS-E6197 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MKL1-Antibody-Center-Blocking-Peptide - BP18838c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MKL1 Blocking Peptide - 33R-7678 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MKL1 fusion protein - Ag15240 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MKL1 fusion protein - ag15308 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human MKL1, GST-tagged - MKL1-893H from Creative Biomart Category Protein Source E.coli Species Human

MRTF-A (H11) Peptide - BS2342P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human MKL/myocardin-like protein 1(MKL1) ,partial - CSB-YP853375HU CSB-EP853375HU CSB-BP853375HU CSB-MP853375HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MKL1 Protein - abx163568 from Abbexa Category Protein Species Human, Mouse, Rat

Mkl1 Recombinant Protein Antigen - NBP1-88498PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MKL1 Peptide, Human - M34GP09543H from Creative Peptides Category Peptide Source Synthetic. Species Human

MKL/myocardin-like protein 1 (MKL1), partial, Recombinant Protein - MBS1476800 from MyBioSource Category Protein Prices $1,005.00, $1,005.00, $1,235.00, $1,235.00, $1,520.00, $1,520.00, $1,975.00, $1,975.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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