Gene Symbol | YAF2 |
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Entrez Gene | 10138 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | YY1 associated factor 2 |
Other Description | YY1-associated factor 2 |
Swissprots | Q99710 Q8IY57 B4DFU3 A8K5P0 G3V465 |
Accessions | EAW57834 EAW57835 EAW57836 EAW57837 EAW57838 EAW57839 EAW57840 Q8IY57 AA789222 AI654632 AK127531 AK291355 BAF84044 AK294260 BAG57554 AK296191 BAG58921 BC037777 AAH37777 BX649019 DA011078 DA491895 EU446625 ABZ92154 EU446756 ABZ92285 XM_006719184 XP_006719247 XM_006719185 XP_006719248 XM_011537728 XP_011536030 XM_011537729 XP_011536031 XR_245886 XR_944464 XR_944466 XR_944467 XR_944468 XR_944469 XR_944470 NM_001190977 NP_001177906 NM_001190979 NP_001177908 NM_001190980 NP_001177909 NM_005748 NP_005739 NR_034000 NM_001012424 |
Function | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11593398}. |
YAF2 CRISPR/Cas9 KO Plasmid (h) - sc-417274 from Santa Cruz Biotechnology
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YAF2 HDR Plasmid (h) - sc-417274-HDR from Santa Cruz Biotechnology
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YAF2 Double Nickase Plasmid (h) - sc-417274-NIC from Santa Cruz Biotechnology
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YAF2 Double Nickase Plasmid (h2) - sc-417274-NIC-2 from Santa Cruz Biotechnology
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YAF2 CRISPR Activation Plasmid (h) - sc-417274-ACT from Santa Cruz Biotechnology
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YAF2 CRISPR Activation Plasmid (h2) - sc-417274-ACT-2 from Santa Cruz Biotechnology
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YAF2 Lentiviral Activation Particles (h) - sc-417274-LAC from Santa Cruz Biotechnology
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YAF2 Lentiviral Activation Particles (h2) - sc-417274-LAC-2 from Santa Cruz Biotechnology
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YAF2 siRNA (h) - sc-95916 from Santa Cruz Biotechnology
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YAF2 shRNA Plasmid (h) - sc-95916-SH from Santa Cruz Biotechnology
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YAF2 shRNA (h) Lentiviral Particles - sc-95916-V from Santa Cruz Biotechnology
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YAF2 RNAi - H00010138-R01 from Novus Biologicals
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MISSION® esiRNA - EHU017891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22994 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22994 from Sigma-Aldrich
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YAF2 siRNA (Human) - CRH6839 from Cohesion Biosciences
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YAF2 RNAi - H00010138-R02 from Novus Biologicals
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YAF2 - MBS8232144 from MyBioSource
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shRNA set against Human YAF2 (NM_005748.4) - SHH448228 from Creative biogene
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Human YAF2 siRNA - orb267341 from Biorbyt
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YAF2 shRNA Plasmid (Human) - CHH6839 from Cohesion Biosciences
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