| Gene Symbol |
MUC20
|
| Entrez Gene |
200958
|
| Alt Symbol |
MUC-20
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mucin 20, cell surface associated
|
| Other Description |
mucin-20|transmembrane mucin MUC20S
|
| Swissprots |
Q76I85 Q6UX97 Q8N307 Q96KA1 Q86ST8 Q9P2I8 Q76I83 Q8NBY6
|
| Accessions |
AFH78580 AFH78584 AFI24895 AFI24896 BAD06720 EAW78022 Q8N307 AB037780 BAA92597 AB098731 BAD06718 AK027314 BAB55035 AK075138 BAC11428 AK298316 BAH12755 AK311504 AY358449 AAQ88814 BC029267 AAH29267 BC044243 AAH44243 BF883124 BM697386 BM721408 BM986861 BP352469 BU685426 DC348309 HG496572 HG496581 HG496582 HG496583 JF432240 ADZ15457 NM_001282506 NP_001269435 NM_001291833 NP_001278762 NM_020790 NP_065841 NM_152673 NP_689886 NM_001098516
|
| Function |
May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. {ECO:0000269|PubMed:15314156}.
|
| Subcellular Location |
Secreted {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:14565953}. Basolateral cell membrane {ECO:0000269|PubMed:14565953}. Cell projection, microvillus membrane {ECO:0000269|PubMed:14565953}.
|
| Tissue Specificity |
Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis. {ECO:0000269|PubMed:14565953, ECO:0000269|PubMed:16997931}.
|