CHCHD4

Gene Symbol	CHCHD4
Entrez Gene	131474
Alt Symbol	MIA40, TIMM40
Species	Human
Gene Type	protein-coding
Description	coiled-coil-helix-coiled-coil-helix domain containing 4
Other Description	coiled-coil-helix-coiled-coil-helix domain-containing protein 4\|mitochondrial intermembrane space import and assembly 40 homolog\|mitochondrial intermembrane space import and assembly protein 40\|translocase of inner mitochondrial membrane 40 homolog
Swissprots	Q96MY6 Q96AI2 Q8N4Q1 A8K3Z9
Accessions	EAW64180 EAW64181 EAW64182 EAW64183 Q8N4Q1 AK056271 BAB71132 AK290764 BAF83453 BC017082 AAH17082 BC033775 AAH33775 DB452249 DB501565 NM_001098502 NP_001091972 NM_144636 NP_653237
Function	Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. {ECO:0000269\|PubMed:16185709, ECO:0000269\|PubMed:19182799, ECO:0000269\|PubMed:21059946, ECO:0000269\|PubMed:23186364}.
Subcellular Location	Mitochondrion intermembrane space {ECO:0000269\|PubMed:16185709, ECO:0000269\|PubMed:23186364}.
Tissue Specificity	Expressed in all tissues tested, suggesting an ubiquitous expression. {ECO:0000269\|PubMed:16185709}.

CHCHD4 (C-12) - sc-365137 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CHCHD4 (C-12): sc-365137. Western blot analysis of CHCHD4 expression in non-transfected: sc-117752 (A) and mouse CHCHD4 transfected: sc-119217 (B) 293T whole cell lysates.

CHCHD4 (D-13) - sc-102436 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

CHCHD4 (H-107) - sc-98628 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CHCHD4 (H-107): sc-98628. Immunoperoxidase staining of formalin fixed, paraffin-embedded human epididymis tissue showing cytoplasmic and membrane staining of glandular cells.

CHCHD4 (K-14) - sc-102437 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 antibody - ab87033 from Abcam

Prices	$378.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 antibody (ab87033) at 1 µg/ml + lysate from MIA40-transfected 293T cells at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-MIA40 antibody - ab128221 from Abcam

Prices	$372.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 antibody - N-terminal - ab181764 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 / CHCHD4 Antibody (N-Terminus) - LS-C153493 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 / CHCHD4 Antibody (aa101-129, FITC) - LS-C237631 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 / CHCHD4 Antibody (aa101-129, PE) - LS-C237632 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 / CHCHD4 Antibody (aa101-129, AP) - LS-C246504 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 / CHCHD4 Antibody (aa101-129, Biotin) - LS-C246506 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 / CHCHD4 Antibody (aa101-129, Azide-free, HRP) - LS-C248815 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 / CHCHD4 Antibody (aa108-137) - LS-C322996 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 / CHCHD4 Antibody (N-Terminus) - LS-C102407 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

CHCHD4 / MIA40 antibody LS-C102407 Western blot of Transfected 293T cell lysate.

Anti-MIA40 / CHCHD4 Antibody (aa101-129, APC) - LS-C246505 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MIA40 / CHCHD4 Antibody (aa101-129) - LS-C164184 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

MIA40 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

CHCHD4 Antibody - NBP1-54783 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CHCHD4 Antibody - NBP1-83537 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: CHCHD4 Antibody [NBP1-83537] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

CHCHD4 Antibody (6C9) - H00131474-M01-100ug from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	6C9

Monoclonal Anti-CHCHD4 antibody produced in mouse - SAB1412920 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	6C9

<B>Immunoblotting</B><BR/>Anti-CHCHD4:<B>Cat. No. SAB1412920</B>: Antibody concentration: 15 μg/mL. Immunofluorescence band of ~16 kDa using HeLa lysate.

Anti-CHCHD4 antibody produced in rabbit - HPA034688 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-CHCHD4: <B>Cat. No. HPA034688</B>: Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.

Anti-CHCHD4, (N-terminal) antibody produced in rabbit - SAB2103206 from Sigma-Aldrich

Prices	$347.50
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-CHCHD4, antibody produced in rabbit: <B>Cat. No. SAB2103206</B>: Immunoblotting analysis of CHCHD4 in transfected 293T cell lysate with CHCHD4 anitbody at 1 μg/mL.

ANTI-MIA40(C-TERMINAL) antibody produced in rabbit - SAB1306211 from Sigma-Aldrich

Prices	$326.00
Sizes	40 tst
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-MIA40 (C-term): <B>Cat. No. SAB1306211</B>: MIA40 Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35 μg/lane).

CHCHD4 antibody - N-terminal region (ARP51895_P050) - ARP51895_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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