CHCHD4

Gene Symbol	CHCHD4
Entrez Gene	131474
Alt Symbol	MIA40, TIMM40
Species	Human
Gene Type	protein-coding
Description	coiled-coil-helix-coiled-coil-helix domain containing 4
Other Description	coiled-coil-helix-coiled-coil-helix domain-containing protein 4|mitochondrial intermembrane space import and assembly 40 homolog|mitochondrial intermembrane space import and assembly protein 40|translocase of inner mitochondrial membrane 40 homolog
Swissprots	Q96MY6 Q96AI2 Q8N4Q1 A8K3Z9
Accessions	EAW64180 EAW64181 EAW64182 EAW64183 Q8N4Q1 AK056271 BAB71132 AK290764 BAF83453 BC017082 AAH17082 BC033775 AAH33775 DB452249 DB501565 NM_001098502 NP_001091972 NM_144636 NP_653237
Function	Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. {ECO:0000269|PubMed:16185709, ECO:0000269|PubMed:19182799, ECO:0000269|PubMed:21059946, ECO:0000269|PubMed:23186364}.
Subcellular Location	Mitochondrion intermembrane space {ECO:0000269|PubMed:16185709, ECO:0000269|PubMed:23186364}.
Tissue Specificity	Expressed in all tissues tested, suggesting an ubiquitous expression. {ECO:0000269|PubMed:16185709}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MIA40 full length protein - ab165346 from Abcam Category Protein Source Wheat germ Species Human

MIA40 / CHCHD4 Antibody Blocking Peptide - LS-E1046 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MIA40 / CHCHD4 Antibody Blocking Peptide - LS-E18620 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CHCHD4 Protein - H00131474-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MIA40-Antibody-C-term-Blocking-peptide - BP11528b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CHCHD4 protein - orb244920 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

CHCHD4 Blocking Peptide - 33R-6527 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CHCHD4 / MIA40 - H00131474-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CHCHD4 / MIA40 - H00131474-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CHCHD4 fusion protein - Ag15339 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

CHCHD4 fusion protein - ag15482 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Mitochondrial intermembrane space import and assembly protein - CSB-YP850802HU CSB-BP850802HU CSB-MP850802HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Mitochondrial intermembrane space import and assembly protein - CSB-EP850802HU from Cusabio Category Protein Source E.coli Species Human

CHCHD4 / MIA40 (transcript variant 1) - TP317831 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human CHCHD4 protein - CHCHD4-34H from Creative Biomart Category Protein Source E.coli Species Human

CHCHD4 Recombinant Protein Antigen - NBP1-83537PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CHCHD4 Peptide, Human - M34GP03067H from Creative Peptides Category Peptide Source Synthetic. Species Human

CHCHD4 Recombinant Protein (OPCA02425) - OPCA02425 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human Mitochondrial intermembrane space import and assembly protein 40 - AP71472 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

CHCHD4 Recombinant Protein Antigen - NBP2-57060PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Mitochondrial intermembrane space import and assembly protein 40, Recombinant Protein - MBS9421336 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

Mitochondrial intermembrane space import and assembly protein 40, Recombinant Protein - MBS1475488 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $880.00, $1,105.00, $1,105.00, $1,180.00, $1,290.00, $1,745.00, $1,745.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant Human CHCHD4 Protein (1-142 aa), His-SUMO-tagged - CHCHD4-1097H from Creative Biomart Category Protein Source E. coli Species Human

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