| Gene Symbol |
CXCL6
|
| Entrez Gene |
6372
|
| Alt Symbol |
CKA-3, GCP-2, GCP2, SCYB6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-X-C motif) ligand 6
|
| Other Description |
C-X-C motif chemokine 6|Small inducible cytokine subfamily B (Cys-X-Cys), member b|chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)|chemokine alpha 3|granulocyte chemotactic protein 2|small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2)|small-inducible cytokine B6
|
| Swissprots |
B2R4X3 P80162 Q4W5D4
|
| Accessions |
AAC51338 AAY40939 EAX05690 P80162 AK311981 BAG34920 BC013744 AAH13744 BP204144 DQ891500 ABM82426 DQ894692 ABM85618 U81234 AAD00506 Y08770 CAA70023 NM_002993 NP_002984
|
| Function |
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram- negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7). {ECO:0000269|PubMed:18443119, ECO:0000269|PubMed:8399143, ECO:0000269|PubMed:8423327, ECO:0000269|PubMed:9057843}.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Rheumatoid arthritis, Pertussis
|
![Western Blot: GCP2 Overexpression Lysate (Adult Normal) [NBL1-09629] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GCP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6561_GCP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09629-img0002.jpg)