Gene Symbol | CXCL6 |
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Entrez Gene | 6372 |
Alt Symbol | CKA-3, GCP-2, GCP2, SCYB6 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-X-C motif) ligand 6 |
Other Description | C-X-C motif chemokine 6|Small inducible cytokine subfamily B (Cys-X-Cys), member b|chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)|chemokine alpha 3|granulocyte chemotactic protein 2|small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2)|small-inducible cytokine B6 |
Swissprots | B2R4X3 P80162 Q4W5D4 |
Accessions | AAC51338 AAY40939 EAX05690 P80162 AK311981 BAG34920 BC013744 AAH13744 BP204144 DQ891500 ABM82426 DQ894692 ABM85618 U81234 AAD00506 Y08770 CAA70023 NM_002993 NP_002984 |
Function | Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram- negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7). {ECO:0000269|PubMed:18443119, ECO:0000269|PubMed:8399143, ECO:0000269|PubMed:8423327, ECO:0000269|PubMed:9057843}. |
Subcellular Location | Secreted. |
Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Rheumatoid arthritis, Pertussis |
GCP-2 CRISPR/Cas9 KO Plasmid (h) - sc-405608 from Santa Cruz Biotechnology
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GCP-2 HDR Plasmid (h) - sc-405608-HDR from Santa Cruz Biotechnology
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GCP-2 Double Nickase Plasmid (h) - sc-405608-NIC from Santa Cruz Biotechnology
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GCP-2 Double Nickase Plasmid (h2) - sc-405608-NIC-2 from Santa Cruz Biotechnology
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GCP-2 CRISPR Activation Plasmid (h) - sc-405608-ACT from Santa Cruz Biotechnology
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GCP-2 CRISPR Activation Plasmid (h2) - sc-405608-ACT-2 from Santa Cruz Biotechnology
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GCP-2 Lentiviral Activation Particles (h) - sc-405608-LAC from Santa Cruz Biotechnology
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GCP-2 Lentiviral Activation Particles (h2) - sc-405608-LAC-2 from Santa Cruz Biotechnology
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GCP-2 siRNA (h) - sc-39350 from Santa Cruz Biotechnology
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GCP-2 shRNA Plasmid (h) - sc-39350-SH from Santa Cruz Biotechnology
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GCP-2 shRNA (h) Lentiviral Particles - sc-39350-V from Santa Cruz Biotechnology
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CXCL6/GCP-2 RNAi - H00006372-R01 from Novus Biologicals
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MISSION® esiRNA - EHU102281 from Sigma-Aldrich
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MISSION® esiRNA - EHU051171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6807 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6807 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08447 from Sigma-Aldrich
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CXCL6 siRNA (Human) - CRH4303 from Cohesion Biosciences
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CXCL6 - MBS8228463 from MyBioSource
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shRNA set against Human CXCL6 (NM_002993.3) - SHH272237 from Creative biogene
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Human CXCL6 siRNA - orb264805 from Biorbyt
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CXCL6 shRNA Plasmid (Human) - CHH4303 from Cohesion Biosciences
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CXCL6 miRNA 3'UTR clone - MiUTR3H-00946 from Creative biogene
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