PARK2

Gene Symbol	PARK2
Entrez Gene	5071
Alt Symbol	AR-JP, LPRS2, PDJ, PRKN
Species	Human
Gene Type	protein-coding
Description	parkin RBR E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase parkin|Parkinson disease (autosomal recessive, juvenile) 2, parkin|parkinson juvenile disease protein 2|parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Swissprots	Q8WW07 Q6Q2I6 D3JZW7 Q5VVX4 A3FG77 Q8NI41 Q8NI43 D3K2X0 Q8NI44 O60260 Q5TFV8 A8K975
Accessions	AAK38595 AAR27057 AAS88420 AAS88421 AAS88422 AAU93631 AAU93632 AAY85310 EAW47571 EAW47572 EAW47573 EAW47574 O60260 AB009973 BAA25751 AB245403 BAF43729 AF381282 AAM21457 AF381283 AAM21458 AF381284 AAM21459 AF381286 AAM21461 AK292590 BAF85279 AK294684 BAG57845 BC022014 AAH22014 DB023187 EF375726 ABN46990 GU345837 GU345838 ADB90269 GU345839 ADB90270 GU345840 ADB90271 GU357501 GU357502 GU361466 ADB91978 GU361467 ADB91979 GU361468 ADB91980 GU361469 ADB91981 GU361470 GU361471 HQ447316 ADQ31803 KC357594 AGH62056 KC357595 AGH62057 KC774171 AGP25366 KJ534911 AHW56551 KJ534912 AHW56552 XM_011535863 XP_011534165 XM_011535864 XP_011534166 XM_011535865 XP_011534167 XM_011535866 XP_011534168 XM_011535867 XP_011534169 NM_004562 NP_004553 NM_013987 NP_054642 NM_013988 NP_054643
Function	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'- linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubM
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:19229105}. Nucleus. Endoplasmic reticulum. Mitochondrion {ECO:0000269|PubMed:19229105}. Note=Mainly localizes in the cytosol. Co-localizes with SYT11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies. Mitochondrial localization gradually increases with cellular growth. Also relocates to dysfunctional mitochondria that have lost the mitochondrial membrane potential; recruitment to mitochondria is PINK1- dependent.
Tissue Specificity	Highly expressed in the brain including the substantia nigra. Expressed in heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients. Overexpression protects dopamine neurons from kainate-mediated apoptosis. Found in serum (at protein level). {ECO:0000269|PubMed:19501131}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PARK2-Over-expression-Lysate - LY10551a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PARK2 293T Cell Transient Overexpression Lysate(Denatured) - H00005071-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PARK2 overexpression lysate - LY415571 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PARK2 overexpression lysate - LY415572 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PARK2 overexpression lysate - LY429401 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PARK2 293 Cell Lysate - 407332 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Parkin Overexpression Lysate (Denatured) - H00005071-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Parkin Overexpression Lysate (Native) - NBL1-14105 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PARK2 Over-expression Lysate Product - GWB-6F82A1 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human PARK2 Knockdown Stable Cell Line - CSC-DC011307 from Creative biogene Category Cell Line Species Human

PARK2 Knockout Cell Line-HeLa - CSC-RT1868 from Creative biogene Category Cell Line Species Human

PARK2 KO Cell Lysate-HeLa - CLKO-1720 from Creative biogene Category Cell Lysate

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