PARK2

Gene Symbol	PARK2
Entrez Gene	5071
Alt Symbol	AR-JP, LPRS2, PDJ, PRKN
Species	Human
Gene Type	protein-coding
Description	parkin RBR E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase parkin|Parkinson disease (autosomal recessive, juvenile) 2, parkin|parkinson juvenile disease protein 2|parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Swissprots	Q8WW07 Q6Q2I6 D3JZW7 Q5VVX4 A3FG77 Q8NI41 Q8NI43 D3K2X0 Q8NI44 O60260 Q5TFV8 A8K975
Accessions	AAK38595 AAR27057 AAS88420 AAS88421 AAS88422 AAU93631 AAU93632 AAY85310 EAW47571 EAW47572 EAW47573 EAW47574 O60260 AB009973 BAA25751 AB245403 BAF43729 AF381282 AAM21457 AF381283 AAM21458 AF381284 AAM21459 AF381286 AAM21461 AK292590 BAF85279 AK294684 BAG57845 BC022014 AAH22014 DB023187 EF375726 ABN46990 GU345837 GU345838 ADB90269 GU345839 ADB90270 GU345840 ADB90271 GU357501 GU357502 GU361466 ADB91978 GU361467 ADB91979 GU361468 ADB91980 GU361469 ADB91981 GU361470 GU361471 HQ447316 ADQ31803 KC357594 AGH62056 KC357595 AGH62057 KC774171 AGP25366 KJ534911 AHW56551 KJ534912 AHW56552 XM_011535863 XP_011534165 XM_011535864 XP_011534166 XM_011535865 XP_011534167 XM_011535866 XP_011534168 XM_011535867 XP_011534169 NM_004562 NP_004553 NM_013987 NP_054642 NM_013988 NP_054643
Function	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'- linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubM
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:19229105}. Nucleus. Endoplasmic reticulum. Mitochondrion {ECO:0000269|PubMed:19229105}. Note=Mainly localizes in the cytosol. Co-localizes with SYT11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies. Mitochondrial localization gradually increases with cellular growth. Also relocates to dysfunctional mitochondria that have lost the mitochondrial membrane potential; recruitment to mitochondria is PINK1- dependent.
Tissue Specificity	Highly expressed in the brain including the substantia nigra. Expressed in heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients. Overexpression protects dopamine neurons from kainate-mediated apoptosis. Found in serum (at protein level). {ECO:0000269|PubMed:19501131}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Parkin full length protein - ab140806 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human Parkin full length protein - ab114219 from Abcam Category Protein Source Wheat germ Species Human

Human Parkin full length protein - ab177625 from Abcam Category Protein Source E. coli Species Human

Human Parkin peptide - ab96283 from Abcam Category Peptide

Human Parkin protein fragment - ab114220 from Abcam Category Protein Source Wheat germ Species Human

Parkin peptide - ab5865 from Abcam Category Peptide

PARK2 / Parkin 2 Antibody Blocking Peptide - LS-E8222 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARK2 / Parkin 2 Antibody Blocking Peptide - LS-E8223 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARK2 / Parkin 2 Antibody Blocking Peptide - LS-E15840 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARK2 / Parkin 2 Blocking Peptide - LS-E26176 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Parkin Protein - H00005071-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Parkin Partial Recombinant Protein - H00005071-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Parkin Peptide - P2044 from Novus Biologicals Category Peptide Species Human

Parkin Peptide - P2043 from Novus Biologicals Category Peptide Species Human

Parkin-Antibody-C-term-Blocking-peptide - BP6402b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Parkin-Antibody-N-term-Blocking-peptide - BP6402a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Parkin blocking peptide - GTX89242-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Human Parkin protein - orb244427 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Park2 Blocking Peptide - 33R-10267 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PARK2 protein (His tag) - 80R-3650 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Parkin Peptide - AC21-1007-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PARK2 / Parkin (1-465, His-tag) - AR51337PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

PARK2 / Parkin (1-465, His-tag) - AR51337PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PARK2 / Parkin - H00005071-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PARK2 / Parkin - H00005071-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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