| Gene Symbol |
SPIRE2
|
| Entrez Gene |
84501
|
| Alt Symbol |
Spir-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spire-type actin nucleation factor 2
|
| Other Description |
protein spire homolog 2|spire actin nucleation factor 2|spire family actin nucleation factor 2|spire homolog 2
|
| Swissprots |
Q8WWL2 Q6P433 A4QPB1 Q96JJ5 Q2TA98 Q8ND47
|
| Accessions |
EAW66680 EAW66681 EAW66682 Q8WWL2 AB058735 BAB47461 AJ422077 CAD19439 AK094918 BAG52954 AK130680 AK130685 AL834408 CAD39070 BC011119 BC063706 AAH63706 BC111030 AAI11031 BC139732 AAI39733 BX439688 XM_006721305 XP_006721368 XM_006721306 XP_006721369 XM_006721307 XP_006721370 XM_011523379 XP_011521681 XM_011523380 XP_011521682 XM_011523381 XP_011521683 XM_011523382 XP_011521684 XM_011523383 XP_011521685 XM_011523384 XP_011521686 XM_011523385 XP_011521687 XR_933461 NM_032451 NP_115827
|
| Function |
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269|PubMed:21620703}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250}.
|
| Top Pathways |
Dorso-ventral axis formation
|
![Western Blot: SPIRE2 Overexpression Lysate (Adult Normal) [NBL1-16411] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPIRE2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9366_SPIRE2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16411-img0002.jpg)