SPIRE2

Gene Symbol SPIRE2
Entrez Gene 84501
Alt Symbol Spir-2
Species Human
Gene Type protein-coding
Description spire-type actin nucleation factor 2
Other Description protein spire homolog 2|spire actin nucleation factor 2|spire family actin nucleation factor 2|spire homolog 2
Swissprots Q8WWL2 Q6P433 A4QPB1 Q96JJ5 Q2TA98 Q8ND47
Accessions EAW66680 EAW66681 EAW66682 Q8WWL2 AB058735 BAB47461 AJ422077 CAD19439 AK094918 BAG52954 AK130680 AK130685 AL834408 CAD39070 BC011119 BC063706 AAH63706 BC111030 AAI11031 BC139732 AAI39733 BX439688 XM_006721305 XP_006721368 XM_006721306 XP_006721369 XM_006721307 XP_006721370 XM_011523379 XP_011521681 XM_011523380 XP_011521682 XM_011523381 XP_011521683 XM_011523382 XP_011521684 XM_011523383 XP_011521685 XM_011523384 XP_011521686 XM_011523385 XP_011521687 XR_933461 NM_032451 NP_115827
Function Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269|PubMed:21620703}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250}.
Top Pathways Dorso-ventral axis formation

Spir-2 CRISPR/Cas9 KO Plasmid (h) - sc-405259 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spir-2 HDR Plasmid (h) - sc-405259-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spir-2 Double Nickase Plasmid (h) - sc-405259-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spir-2 Double Nickase Plasmid (h2) - sc-405259-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spir-2 CRISPR Activation Plasmid (h) - sc-405259-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spir-2 CRISPR Activation Plasmid (h2) - sc-405259-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spir-2 Lentiviral Activation Particles (h) - sc-405259-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spir-2 Lentiviral Activation Particles (h2) - sc-405259-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spir-2 siRNA (h) - sc-93231 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Spir-2 shRNA Plasmid (h) - sc-93231-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Spir-2 shRNA (h) Lentiviral Particles - sc-93231-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN20495 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20495 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08239 from Sigma-Aldrich

Category miRNA

SPIRE2 siRNA (Human) - CRJ3495 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPIRE2 - MBS8224124 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SPIRE2 (NM_032451.1) - SHH416920 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SPIRE2(NM_032451.1) - SHL029520 from Creative biogene

Category siRNA
Species Reactivities Human

SPIRE2 shRNA Plasmid (Human) - CHJ3495 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SPIRE2 miRNA 3'UTR clone - MiUTR1H-09854 from Creative biogene

Species Reactivities Human
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