SPIRE2

Gene Symbol	SPIRE2
Entrez Gene	84501
Alt Symbol	Spir-2
Species	Human
Gene Type	protein-coding
Description	spire-type actin nucleation factor 2
Other Description	protein spire homolog 2|spire actin nucleation factor 2|spire family actin nucleation factor 2|spire homolog 2
Swissprots	Q8WWL2 Q6P433 A4QPB1 Q96JJ5 Q2TA98 Q8ND47
Accessions	EAW66680 EAW66681 EAW66682 Q8WWL2 AB058735 BAB47461 AJ422077 CAD19439 AK094918 BAG52954 AK130680 AK130685 AL834408 CAD39070 BC011119 BC063706 AAH63706 BC111030 AAI11031 BC139732 AAI39733 BX439688 XM_006721305 XP_006721368 XM_006721306 XP_006721369 XM_006721307 XP_006721370 XM_011523379 XP_011521681 XM_011523380 XP_011521682 XM_011523381 XP_011521683 XM_011523382 XP_011521684 XM_011523383 XP_011521685 XM_011523384 XP_011521686 XM_011523385 XP_011521687 XR_933461 NM_032451 NP_115827
Function	Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269|PubMed:21620703}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250}.
Top Pathways	Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SPIRE2 Antibody Blocking Peptide - LS-E333 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPIRE2 Antibody Blocking Peptide - LS-E22096 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPIRE2-Antibody-Center-Blocking-Peptide - BP10600c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPIRE2 Blocking Peptide - 33R-2279 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SPIRE2 fusion protein - Ag12091 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SPIRE2 fusion protein - ag12117 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SPIRE2, His-tagged - SPIRE2-2923H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Protein spire homolog 2(SPIRE2) - CSB-YP855490HU CSB-EP855490HU CSB-BP855490HU CSB-MP855490HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SPIRE2 - TP315650 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SPIRE2 Recombinant Protein Antigen - NBP2-47261PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SPIRE2 Recombinant Protein Antigen - NBP2-30506PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SPIRE2 Peptide, Human - M34GP15068H from Creative Peptides Category Peptide Source Synthetic. Species Human

Protein spire homolog 2 (SPIRE2), Recombinant Protein - MBS1432612 from MyBioSource Category Protein Prices $1,525.00, $1,525.00, $1,750.00, $1,750.00, $2,610.00, $2,610.00, $3,050.00, $3,050.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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