CDC73

Gene Symbol	CDC73
Entrez Gene	79577
Alt Symbol	C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX
Species	Human
Gene Type	protein-coding
Description	cell division cycle 73
Other Description	Paf1/RNA polymerase II complex component|cell division cycle 73, Paf1/RNA polymerase II complex component, homolog|cell division cycle protein 73 homolog|hyperparathyroidism 2 protein|parafibromin
Swissprots	B2RBR2 A6NLZ8 Q9H5L7 Q9H245 Q96A07 Q6P1J9 Q6PK51
Accessions	EAW91250 Q6P1J9 AF312865 AAG45339 AI638120 AK026969 BAB15608 AK226038 AK300929 BAG62559 AK314772 BAG37309 BC007325 AAH07325 BC013075 BC014351 AAH14351 BC065037 AAH65037 BM471846 BU428536 DC298135 EU831787 ACE87305 EU831865 ACE86624 XM_006711537 XP_006711600 NM_024529 NP_078805
Function	Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622}.
Tissue Specificity	Found in adrenal and parathyroid glands, kidney and heart. {ECO:0000269|PubMed:15580289}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CDC73 (D38E12) Rabbit mAb - 8126 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D38E12

CDC73 (A264) Antibody - 3644 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

CDC73 (D410) Antibody - 3645 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Parafibromin (A-8) - sc-271877 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Parafibromin (G-11) - sc-365053 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Parafibromin (S-20) - sc-46227 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Parafibromin (G-9) - sc-365749 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Parafibromin (H-300) - sc-48770 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Parafibromin (E-12) - sc-271820 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Parafibromin (E-4) - sc-373792 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Parafibromin (C-17) - sc-46224 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Parafibromin (P-18) - sc-46226 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Parafibromin (H-16) - sc-46225 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Parafibromin (2H1) - sc-33638 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-HRPT2 antibody [EPR9218] - ab139189 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR9218

Anti-HRPT2 antibody [EPR9219] - ab139187 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR9219

Anti-CDC73 / Parafibromin Antibody (aa250-300) - LS-C93038 from LifeSpan Bioscience Prices $545.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CDC73 / Parafibromin Antibody (aa375-425) - LS-C93039 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CDC73 / Parafibromin Antibody (aa139-169, AP) - LS-C208309 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CDC73 / Parafibromin Antibody (aa139-169, APC) - LS-C208310 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CDC73 / Parafibromin Antibody (aa139-169, Biotin) - LS-C208311 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CDC73 / Parafibromin Antibody (aa139-169, Azide-free, HRP) - LS-C208313 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CDC73 / Parafibromin Antibody (aa139-169, FITC) - LS-C208312 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CDC73 / Parafibromin Antibody (aa385-434) - LS-C151536 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CDC73 / Parafibromin Antibody (aa139-169, PE) - LS-C208314 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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