| Gene Symbol | CDC73 |
|---|---|
| Entrez Gene | 79577 |
| Alt Symbol | C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell division cycle 73 |
| Other Description | Paf1/RNA polymerase II complex component|cell division cycle 73, Paf1/RNA polymerase II complex component, homolog|cell division cycle protein 73 homolog|hyperparathyroidism 2 protein|parafibromin |
| Swissprots | B2RBR2 A6NLZ8 Q9H5L7 Q9H245 Q96A07 Q6P1J9 Q6PK51 |
| Accessions | EAW91250 Q6P1J9 AF312865 AAG45339 AI638120 AK026969 BAB15608 AK226038 AK300929 BAG62559 AK314772 BAG37309 BC007325 AAH07325 BC013075 BC014351 AAH14351 BC065037 AAH65037 BM471846 BU428536 DC298135 EU831787 ACE87305 EU831865 ACE86624 XM_006711537 XP_006711600 NM_024529 NP_078805 |
| Function | Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622}. |
| Tissue Specificity | Found in adrenal and parathyroid glands, kidney and heart. {ECO:0000269|PubMed:15580289}. |
Parafibromin CRISPR/Cas9 KO Plasmid (h) - sc-401334 from Santa Cruz Biotechnology
|
||||||||
Parafibromin HDR Plasmid (h) - sc-401334-HDR from Santa Cruz Biotechnology
|
||||||||
Parafibromin Double Nickase Plasmid (h) - sc-401334-NIC from Santa Cruz Biotechnology
|
||||||||
Parafibromin Double Nickase Plasmid (h2) - sc-401334-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Parafibromin CRISPR Activation Plasmid (h) - sc-401334-ACT from Santa Cruz Biotechnology
|
||||||||
Parafibromin CRISPR Activation Plasmid (h2) - sc-401334-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Parafibromin Lentiviral Activation Particles (h) - sc-401334-LAC from Santa Cruz Biotechnology
|
||||||||
Parafibromin Lentiviral Activation Particles (h2) - sc-401334-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Parafibromin siRNA (h) - sc-45528 from Santa Cruz Biotechnology
|
||||||||
Parafibromin shRNA Plasmid (h) - sc-45528-SH from Santa Cruz Biotechnology
|
||||||||
Parafibromin shRNA (h) Lentiviral Particles - sc-45528-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU037101 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN5797 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5797 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR08499 from Sigma-Aldrich
|
||||||||
CDC73 siRNA (Human) - CRJ2404 from Cohesion Biosciences
|
||||||||
CDC73 - MBS8209582 from MyBioSource
|
||||||||
shRNA set against Human CDC73 (NM_024529.4) - SHH259993 from Creative biogene
|
||||||||
CDC73 shRNA Plasmid (Human) - CHJ2404 from Cohesion Biosciences
|
||||||||
CDC73 miRNA 3'UTR clone - MiUTR4H-TG01910 from Creative biogene
|