CDC73

Gene Symbol	CDC73
Entrez Gene	79577
Alt Symbol	C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX
Species	Human
Gene Type	protein-coding
Description	cell division cycle 73
Other Description	Paf1/RNA polymerase II complex component|cell division cycle 73, Paf1/RNA polymerase II complex component, homolog|cell division cycle protein 73 homolog|hyperparathyroidism 2 protein|parafibromin
Swissprots	B2RBR2 A6NLZ8 Q9H5L7 Q9H245 Q96A07 Q6P1J9 Q6PK51
Accessions	EAW91250 Q6P1J9 AF312865 AAG45339 AI638120 AK026969 BAB15608 AK226038 AK300929 BAG62559 AK314772 BAG37309 BC007325 AAH07325 BC013075 BC014351 AAH14351 BC065037 AAH65037 BM471846 BU428536 DC298135 EU831787 ACE87305 EU831865 ACE86624 XM_006711537 XP_006711600 NM_024529 NP_078805
Function	Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622}.
Tissue Specificity	Found in adrenal and parathyroid glands, kidney and heart. {ECO:0000269|PubMed:15580289}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HRPT2 full length protein - ab164037 from Abcam Category Protein Source Wheat germ Species Human

Human HRPT2 peptide - ab23385 from Abcam Category Peptide

Human HRPT2 protein fragment - ab152063 from Abcam Category Protein Source E. coli Species Human

CDC73 / Parafibromin Antibody Blocking Peptide - LS-E23216 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDC73 / Parafibromin Antibody Blocking Peptide - LS-E23215 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDC73 / Parafibromin Antibody Blocking Peptide - LS-E9989 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CDC73/HRPT2 Protein - H00079577-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

CDC73-Antibody-Center-Blocking-Peptide - BP9181c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CDC73 protein - orb49572 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Parafibromin - H00079577-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

CDC73, Parafibromin, Human, Recombinant - 19-CE45 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

HRPT2; CDC73 fusion protein - Ag2959 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Parafibromin Peptide - 350517 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human PARK2 Protein - BP002620-CF59 from Syd Labs Category Protein Prices $180.00, $528.00, $2,880.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human CDC73, His-tagged - CDC73-7927H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human CDC73, GST-tagged - CDC73-11020H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Parafibromin(CDC73) - CSB-YP750783HU CSB-EP750783HU CSB-BP750783HU CSB-MP750783HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Parafibromin - TP309479 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Parafibromin (CDC73), Recombinant Protein - MBS1429499 from MyBioSource Category Protein Prices $1,320.00, $1,320.00, $1,540.00, $1,540.00, $2,180.00, $2,180.00, $2,645.00, $2,645.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CDC73-Antibody-Center-Blocking-Peptide - BP9173c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CDC73-Blocking-Peptide-Center - BP21710c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CDC73 Peptide, Human - M34GP02820H from Creative Peptides Category Peptide Source Synthetic. Species Human

CDC73 Recombinant Protein - 92-011 from ProSci Category Protein Prices $425.00 Sizes 50 µg Source E. coli Species Human

CDC73/HRPT2 Recombinant Protein Antigen - NBP2-55257PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CDC73, Recombinant Protein - MBS8248748 from MyBioSource Category Protein Prices $205.00, $465.00, $2,080.00 Sizes 10 µg, 50 µg, 500 µg Source E Coli Species Human

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