TOB1

Gene Symbol	TOB1
Entrez Gene	10140
Alt Symbol	APRO6, PIG49, TOB, TROB, TROB1
Species	Human
Gene Type	protein-coding
Description	transducer of ERBB2, 1
Other Description	proliferation-inducing gene 49\|protein Tob1\|transducer of erbB-2 1
Swissprots	B2R9T0 D3DTY3 Q4KMQ0 P50616
Accessions	EAW94577 EAW94578 P50616 AA675891 AK313904 BAG36627 AY524047 AAS94256 BC031406 AAH31406 BC070493 AAH70493 BC098415 AAH98415 BT019380 AAV38187 BT019381 AAV38188 CR536487 CAG38726 CR541686 CAG46487 D38305 BAA07423 DA039934 DQ890837 ABM81763 DQ893992 ABM84918 DQ893993 ABM84919 NM_001243877 NP_001230806 NM_001243885 NP_001230814 NM_005749 NP_005740
Function	Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. {ECO:0000269\|PubMed:23236473, ECO:0000269\|PubMed:8632892}.
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. {ECO:0000250}.
Tissue Specificity	Ubiquitous.
Top Pathways	RNA degradation

TOB1 (H-70) - sc-33192 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

TOB1 (H-70): sc-33192. Western blot analysis of TOB1 expression in mouse brain tissue extract.

TOB1 (K-18) - sc-18549 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TOB1 (E-1) - sc-133095 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

TOB1 (E-1): sc-133095. Western blot analysis of TOB1 expression in non-transfected: sc-117752 (A) and human TOB1 transfected: sc-111567 (B) 293T whole cell lysates.

TOB1 (D-7) - sc-136969 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

TOB1 (D-7): sc-136969. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervix tissue showing cytoplasmic staining of squamous epithelial cells.

Anti-TOB (phospho S164) antibody - ab78915 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

ab78915 at 1/50 dilution staining TOB in human brain by Immunohistochemistry using paraffin-embedded tissue, in the absence or presence of the immunising phosphopeptide.

Anti-TOB antibody - ab168947 from Abcam

Prices	$384.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-TOB antibody (ab168947) at 1 µg/mlLane 1 : TOB transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-TOB antibody - ab79372 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-TOB antibody (ab79372) at 1/500 dilutionLane 1 : HT29 cell extracts, treated with serum (20%, 15mins)Lane 2 : HT29 cell extracts, treated with serum (20%, 15mins) with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-TOB antibody - ab48826 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOB antibody (ab48826) at 1.25 µg/ml + NIH 3T3 lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TOB antibody - ab91325 from Abcam

Host	Rabbit
Clonality	Polyclonal

Anti-TOB antibody (ab91325) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

Anti-TOB1 / TOB Antibody - LS-C26768 from LifeSpan Bioscience

Prices	$330.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TOB1 / TOB Antibody - LS-C194061 from LifeSpan Bioscience

Prices	$905.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TOB1 / TOB Antibody (N-Terminus, APC) - LS-C283618 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOB1 / TOB Antibody (N-Terminus, Biotin) - LS-C283619 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOB1 / TOB Antibody (N-Terminus, AP) - LS-C283620 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOB1 / TOB Antibody (N-Terminus, FITC) - LS-C283621 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOB1 / TOB Antibody (aa173-222) - LS-C30874 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TOB1 / TOB Antibody (N-Terminus, Azide-free, HRP) - LS-C283625 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOB1 / TOB Antibody (N-Terminus, PE) - LS-C283626 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOB1 / TOB Antibody (aa215-264) - LS-C117236 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

TOB1 antibody LS-C117236 Western blot of Jurkat lysate.

Anti-TOB1 / TOB Antibody (N-Terminus) - LS-C330696 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TOB1 / TOB Antibody (N-Terminus) - LS-C345499 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of TOB1 Antibody with human Ovary Tumor lysate.

Anti-TOB1 / TOB Antibody (aa130-179) - LS-C118378 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded human brain tissue, using TOB1 (Ab-164) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-TOB1 / TOB Antibody (phospho-Ser164) - LS-C199672 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded human brain, using TOB1 (Phospho-Ser164) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-TOB1 / TOB Antibody (aa54-83) - LS-C160103 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with TOB1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

TOB1 Antibody - AF5228 from Novus Biologicals

Prices	$99.00, $329.00
Sizes	25 µg, 100 µg
Host	Goat
Clonality	Polyclonal

Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, 293T human embryonic kidney cell line, and MCF‑7 human breast cancer cell line. PVDF membrane was probed with 2 µg/mL of Human TOB1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5228) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for TOB1 at approximately 52 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

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