| Gene Symbol |
TOB1
|
| Entrez Gene |
10140
|
| Alt Symbol |
APRO6, PIG49, TOB, TROB, TROB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transducer of ERBB2, 1
|
| Other Description |
proliferation-inducing gene 49|protein Tob1|transducer of erbB-2 1
|
| Swissprots |
B2R9T0 D3DTY3 Q4KMQ0 P50616
|
| Accessions |
EAW94577 EAW94578 P50616 AA675891 AK313904 BAG36627 AY524047 AAS94256 BC031406 AAH31406 BC070493 AAH70493 BC098415 AAH98415 BT019380 AAV38187 BT019381 AAV38188 CR536487 CAG38726 CR541686 CAG46487 D38305 BAA07423 DA039934 DQ890837 ABM81763 DQ893992 ABM84918 DQ893993 ABM84919 NM_001243877 NP_001230806 NM_001243885 NP_001230814 NM_005749 NP_005740
|
| Function |
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. {ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
RNA degradation
|
