| Gene Symbol |
SGPP2
|
| Entrez Gene |
130367
|
| Alt Symbol |
SPP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sphingosine-1-phosphate phosphatase 2
|
| Other Description |
SPPase2|hSPP2|sphingosine 1-phosphate phosphohydrolase 2|sphingosine-1-phosphatase 2|sphingosine-1-phosphate phosphotase 2
|
| Swissprots |
Q8IWX5 Q8N8Q6 A3KPB4
|
| Accessions |
AAX88957 AAY24195 EAW70801 Q8IWX5 AF542512 AAN28731 AK096323 BAC04762 AK314322 BAG36970 BC106904 AAI06905 BC106905 AAI06906 BC114513 BC134342 AAI34343 XM_005246297 XP_005246354 NM_152386 NP_689599
|
| Function |
Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. {ECO:0000269|PubMed:12411432, ECO:0000269|PubMed:17113265}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:12411432}; Multi-pass membrane protein {ECO:0000269|PubMed:12411432}.
|
| Tissue Specificity |
Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. {ECO:0000269|PubMed:12411432}.
|
| Top Pathways |
Sphingolipid signaling pathway, Sphingolipid metabolism
|