SGPP2

Gene Symbol	SGPP2
Entrez Gene	130367
Alt Symbol	SPP2
Species	Human
Gene Type	protein-coding
Description	sphingosine-1-phosphate phosphatase 2
Other Description	SPPase2\|hSPP2\|sphingosine 1-phosphate phosphohydrolase 2\|sphingosine-1-phosphatase 2\|sphingosine-1-phosphate phosphotase 2
Swissprots	Q8IWX5 Q8N8Q6 A3KPB4
Accessions	AAX88957 AAY24195 EAW70801 Q8IWX5 AF542512 AAN28731 AK096323 BAC04762 AK314322 BAG36970 BC106904 AAI06905 BC106905 AAI06906 BC114513 BC134342 AAI34343 XM_005246297 XP_005246354 NM_152386 NP_689599
Function	Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. {ECO:0000269\|PubMed:12411432, ECO:0000269\|PubMed:17113265}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:12411432}; Multi-pass membrane protein {ECO:0000269\|PubMed:12411432}.
Tissue Specificity	Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. {ECO:0000269\|PubMed:12411432}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

SPPase2 (K-16) - sc-55048 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

SPPase2 (K-25) - sc-134030 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

SPPase2 (K-25): sc-134030. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing cytoplasmic localization.

Anti-Sphingosine 1 phosphate phosphatase 2 antibody - N-terminal - ab173888 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Sphingosine 1 phosphate phosphatase 2 antibody - N-terminal (ab173888) at 1/100 dilution + NCI-H460 cell lysate at 35 µg

Anti-SGPP2 Antibody - LS-C26809 from LifeSpan Bioscience

Prices	$480.00
Sizes	10 blot
Host	Rabbit
Clonality	Polyclonal

Anti-SGPP2 Antibody (aa7-33, AP) - LS-C240723 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SGPP2 Antibody (aa7-33, APC) - LS-C240724 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SGPP2 Antibody (aa7-33, FITC) - LS-C240726 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SGPP2 Antibody (aa7-33, Biotin) - LS-C240725 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SGPP2 Antibody (aa7-33, PE) - LS-C240728 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SGPP2 Antibody (aa7-33, Azide-free, HRP) - LS-C248146 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SGPP2 Antibody (aa6-33) - LS-C325070 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SGPP2 Antibody (aa7-33) - LS-C158961 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

SGPP2 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The SGPP2 antibody detected the SGPP2 protein (arrow).

Anti-SGPP2 Antibody (aa301-350) - LS-C40533 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

SGPP2 antibody LS-C40533 IHC of formalin-fixed, paraffin-embedded human Kidney. Positive label: Epithelial cells of renal tubule indicated with arrows. Antibody concentration 4-8 ug/ml. Magnification 400X.

Sphingosine 1 phosphate phosphatase 2 Antibody - NBP1-53181 from Novus Biologicals

Prices	$299.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SPP2 Antibody - NBP2-13373 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: SPP2 Antibody [NBP2-13373] Staining of human duodenum shows strong cytoplasmic positivity in subset of glandular cells.

SPP2 Antibody - NBP1-19025 from Novus Biologicals

Prices	$329.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

ANTI-SGPP2 (N-TERM) antibody produced in rabbit - SAB1304214 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-SGPP2 (N-term): <B>Cat. No. SAB1304214</B>: SGPP2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35 μg/lane).

Anti-SGPP2 antibody produced in rabbit - AV45734 from Sigma-Aldrich

Prices	$267.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-SGPP2: <B>Cat. No. AV45734</B>: Immunohistochemistry of SGPP2 in Human Kidney tissue with SGPP2 antibody at 4-8 μg/mL.

SGPP2 antibody - C-terminal region (ARP45734_T100) - ARP45734_T100 from Aviva Systems Biology

Prices	$229.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SGPP2-Antibody-N-term - AP18254a from Abgent, a WuXi AppTec company

Prices	$99.00, $295.00
Sizes	80 µl, 400 µl
Host	Rabbit
Clonality	Polyclonal

SGPP2 Antibody (N-term) (Cat. #AP18254a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SGPP2 antibody detected the SGPP2 protein (arrow).

SGPP2 Antibody - N-terminal region (OAAB13773) - OAAB13773 from Aviva Systems Biology

Prices	$289.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

SGPP2 antibody - 70R-1195 from Fitzgerald

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

SGPP2 Antibody - abx030143 from Abbexa

Host	Rabbit
Clonality	Polyclonal

SGPP2 antibody - AP05170PU-N from Acris Antibodies

Prices	$490.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis using S1P Phosphatase 2 antibody on human brain lysate.

SGPP2 Antibody - 30-109 from ProSci

Prices	$250.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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